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<p>This letter to the editor identifies a critical methodological concern in a recent clinical trial by Qin et al. that compared the emergence profiles of remimazolam and propofol in pediatric anesthesia. We argue that the study’s findings are confounded by a fundamental"asymmetry in interventions”. The remimazolam group routinely received flumazenil for pharmacological reversal, while the propofol group emerged spontaneously via natural metabolism.</p>

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Routine flumazenil administration confounds emergence time comparisons between remimazolam and propofol: a methodological concern

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月24日

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  • Haishan Cui,
  • Qingjun Zeng,
  • Yi Zhang

摘要

This letter to the editor identifies a critical methodological concern in a recent clinical trial by Qin et al. that compared the emergence profiles of remimazolam and propofol in pediatric anesthesia. We argue that the study’s findings are confounded by a fundamental"asymmetry in interventions”. The remimazolam group routinely received flumazenil for pharmacological reversal, while the propofol group emerged spontaneously via natural metabolism.