Scholarlink

Background <p>To evaluate the safety and efficacy of dexmedetomidine combined with butorphanol for postoperative analgesia in patients undergoing posterior spinal surgery.</p> Methods <p>60 Patients undergoing posterior spinal surgery were randomly divided into two groups: the butorphanol 0.125&#xa0;mg/kg group (group B, <i>n</i> = 30) and the butorphanol 0.125&#xa0;mg/kg combined with dexmedetomidine 0.1&#xa0;µg/kg/h group (group DB, <i>n</i> = 30). The postoperative pain, degree of sedation, adverse drug reactions, and total satisfaction rate of the two groups were recorded.</p> Results <p>A total of 60 patients completed the study (Group B, <i>n</i> = 30; DB group, <i>n</i> = 30), and the baseline characteristics (age, gender, BMI) of the two groups were essentially similar (<i>p</i> &gt; 0.05). The Visual Analog Scale (VAS) scores at rest and during exercise in group DB were significantly lower than those in group B (<i>P</i> &lt; 0.05). The number of pressings in group B was significantly higher than that in group DB (<i>P</i> &lt; 0.05). The Ramsay Sedation Score in group DB was higher than that in group B at T1, T2 (<i>P</i> &lt; 0.05). Compared with group B, the incidence of nausea was significantly decreased in group DB (<i>P</i> &lt; 0.05). Compared with group B, the total satisfaction rate of patients in group DB was significantly higher (<i>P</i> &lt; 0.05).</p> Conclusion <p>Dexmedetomidine can enhance the analgesic effect of butorphanol after posterior spinal surgery.</p> Trial registration <p>The study protocol was approved by the hospital ethics committee at Zigong Hospital of Traditional Chinese Medicine, China, and the trial was registered at the Chinese Clinical Trial Registry (Registration Number: ChiCTR2400093015; Date: 27th, Nov, 2024). It was conducted from December 2024 to June 2025.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Effect of postoperative analgesia with the combination of dexmedetomidine and butorphanol after spinal posterior surgery: a randomized controlled trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月3日

查看全文
  • Zi-Feng Xie,
  • Bo-Ran Deng,
  • Yuan Gao,
  • Yi-Dan Zhang,
  • Yu-Ting Meng,
  • Tu Shen,
  • Qiao-Ling Wu

摘要

Background

To evaluate the safety and efficacy of dexmedetomidine combined with butorphanol for postoperative analgesia in patients undergoing posterior spinal surgery.

Methods

60 Patients undergoing posterior spinal surgery were randomly divided into two groups: the butorphanol 0.125 mg/kg group (group B, n = 30) and the butorphanol 0.125 mg/kg combined with dexmedetomidine 0.1 µg/kg/h group (group DB, n = 30). The postoperative pain, degree of sedation, adverse drug reactions, and total satisfaction rate of the two groups were recorded.

Results

A total of 60 patients completed the study (Group B, n = 30; DB group, n = 30), and the baseline characteristics (age, gender, BMI) of the two groups were essentially similar (p > 0.05). The Visual Analog Scale (VAS) scores at rest and during exercise in group DB were significantly lower than those in group B (P < 0.05). The number of pressings in group B was significantly higher than that in group DB (P < 0.05). The Ramsay Sedation Score in group DB was higher than that in group B at T1, T2 (P < 0.05). Compared with group B, the incidence of nausea was significantly decreased in group DB (P < 0.05). Compared with group B, the total satisfaction rate of patients in group DB was significantly higher (P < 0.05).

Conclusion

Dexmedetomidine can enhance the analgesic effect of butorphanol after posterior spinal surgery.

Trial registration

The study protocol was approved by the hospital ethics committee at Zigong Hospital of Traditional Chinese Medicine, China, and the trial was registered at the Chinese Clinical Trial Registry (Registration Number: ChiCTR2400093015; Date: 27th, Nov, 2024). It was conducted from December 2024 to June 2025.