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Background <p>Oxaliplatin is widely used as a chemotherapeutic agent for treating various cancers, including colorectal cancer. However, oxaliplatin-induced peripheral neuropathy diminishes the quality of life of patients. Thus, the development of preventive or therapeutic drugs for oxaliplatin-induced peripheral neuropathy is urgently needed. Herein, we aimed to investigate whether PC-SOD, a derivative of SOD with higher stability in plasma and higher affinity for tissues, could prevent oxaliplatin-induced peripheral neuropathy.</p> Results <p>PC-SOD significantly attenuated oxaliplatin-induced neurite damage and reduced oxaliplatin-induced reactive oxygen species (ROS) production in cultured PC12 cells. In a rat model, PC-SOD reduced oxaliplatin-induced mechanical allodynia, cold hyperalgesia, and morphological damage to intraepidermal nerve fibers and dorsal root ganglion. Furthermore, PC-SOD did not significantly affect the antitumor effects of oxaliplatin in cultured tumor cells or in tumor cell-implanted mice.</p> Conclusion <p>These findings indicated that PC-SOD alleviated oxaliplatin-induced mechanical allodynia, cold hyperalgesia, and neural damage without significantly affecting the antitumor activity of oxaliplatin. Therefore, PC-SOD is a promising drug candidate for the prevention of oxaliplatin-induced peripheral neuropathy.</p>

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Preventive effect of PC-SOD on oxaliplatin-induced peripheral neuropathy in rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月22日

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  • Zhiwei Qiao,
  • Yuki Uchihara,
  • Naohiro Tsukiyama,
  • Shota Akimoto,
  • Noriko Kaji,
  • Koichiro Fukuda,
  • Tohru Mizushima

摘要

Background

Oxaliplatin is widely used as a chemotherapeutic agent for treating various cancers, including colorectal cancer. However, oxaliplatin-induced peripheral neuropathy diminishes the quality of life of patients. Thus, the development of preventive or therapeutic drugs for oxaliplatin-induced peripheral neuropathy is urgently needed. Herein, we aimed to investigate whether PC-SOD, a derivative of SOD with higher stability in plasma and higher affinity for tissues, could prevent oxaliplatin-induced peripheral neuropathy.

Results

PC-SOD significantly attenuated oxaliplatin-induced neurite damage and reduced oxaliplatin-induced reactive oxygen species (ROS) production in cultured PC12 cells. In a rat model, PC-SOD reduced oxaliplatin-induced mechanical allodynia, cold hyperalgesia, and morphological damage to intraepidermal nerve fibers and dorsal root ganglion. Furthermore, PC-SOD did not significantly affect the antitumor effects of oxaliplatin in cultured tumor cells or in tumor cell-implanted mice.

Conclusion

These findings indicated that PC-SOD alleviated oxaliplatin-induced mechanical allodynia, cold hyperalgesia, and neural damage without significantly affecting the antitumor activity of oxaliplatin. Therefore, PC-SOD is a promising drug candidate for the prevention of oxaliplatin-induced peripheral neuropathy.