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Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年7月8日

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  • Shubhra Acharya,
  • Andrew I. Lumley,
  • Yvan Devaux,
  • Muhammad Ali,
  • Nancy E. Ramia,
  • Giuseppe Arena,
  • Rudi Balling,
  • Michele Bassis,
  • Regina Becker,
  • Ibrahim Boussaad,
  • Piotr Gawron,
  • Soumyabrata Ghosh,
  • Enrico Glaab,
  • Elisa Gómez De Lope,
  • Valentin Groues,
  • Anne Grünewald,
  • Wei Gu,
  • Michael Heneka,
  • Sascha Herzinger,
  • Jacek Jaroslaw Lebioda,
  • Yohan Jaroz,
  • Quentin Klopfenstein,
  • Zied Landoulsi,
  • Tainá M. Marques,
  • Patricia Martins Conde,
  • Patrick May,
  • Francoise Meisch,
  • Sarah Nickels,
  • Marek Ostaszewski,
  • Clarissa P. C. Gomes,
  • Sinthuja Pachchek,
  • Armin Rauschenberger,
  • Rajesh Rawal,
  • Dheeraj Reddy Bobbili,
  • Kirsten Roomp,
  • Isabel Rosety,
  • Stefano Sapienza,
  • Venkata Satagopam,
  • Sabine Schmitz,
  • Reinhard Schneider,
  • Jens Schwamborn,
  • Ekaterina Soboleva,
  • Rebecca Ting Jiin Loo,
  • Christophe Trefois,
  • Carlos Vega,
  • Maharshi Vyas,
  • Paul Wilmes,
  • Evi Wollscheid-Lengeling,
  • Jochen Klucken,
  • Rejko Krüger,
  • Claire Pauly,
  • Lukas Pavelka,
  • Linda Hansen,
  • Gilles van Cutsem,
  • Geeta Acharya,
  • Gloria Aguayo,
  • Myriam Alexandre,
  • Wim Ammerlann,
  • Katy Beaumont,
  • Camille Bellora,
  • Jessica Calmes,
  • Lorieza Castillo,
  • Gessica Contesotto,
  • Daniela Esteves,
  • Guy Fagherazzi,
  • Jean-Yves Ferrand,
  • Marijus Giraitis,
  • Jérôme Graas,
  • Gaël Hammot,
  • Anne-Marie Hanff,
  • Estelle Henry,
  • Michael Heymann,
  • Alexander Hundt,
  • Sonja Jónsdóttir,
  • Pauline Lambert,
  • Victoria Lorentz,
  • Paula Cristina Lupu,
  • Guilherme Marques,
  • Deborah Mcintyre,
  • Chouaib Mediouni,
  • Myriam Menster,
  • Maura Minelli,
  • Ulf Nehrbass,
  • Fozia Noor,
  • Magali Perquin,
  • Rosalina Ramos Lima,
  • Eduardo Rosales,
  • Estelle Sandt,
  • Margaux Schmitt,
  • Amir Sharify,
  • Kate Sokolowska,
  • Hermann Thien,
  • Johanna Trouet,
  • Olena Tsurkalenko,
  • Michel Vaillant,
  • Mesele Valenti,
  • Guy Berchem,
  • Nico Diederich,
  • Liliana Vilas Boas,
  • Gelani Zelimkhanov,
  • Laura Longhino,
  • Romain Nati,
  • Beatrice Nicolai,
  • Elodie Thiry,
  • Friedrich Mühlschlegel,
  • Alexandre Bisdorff,
  • Rene Dondelinger,
  • Sylvia Herbrink,
  • Roseline Lentz,
  • Michele Hu,
  • Richard Wade-Martins,
  • Clare Mackay,
  • Daniela Berg,
  • Kathrin Brockmann,
  • Thomas Gasser,
  • Inga Liepelt,
  • Brit Mollenhauer,
  • Katrin Marcus,
  • Robert Liszka,
  • Walter Maetzler,
  • Mariella Graziano,
  • Nadine Jacoby,
  • Jean-Paul Nicolay,
  • Laure Pauly,
  • Michel Mittelbronn

摘要

Background

Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to the development of severe autonomic dysfunction. One of the initial indicators of PD is the appearance of cardiovascular dysautonomia. As such, it is vital to monitor and manage cardiovascular health of individuals with PD, as it may have clinical implications in the development of commonly recognized motor and non-motor aspects of the disease. To study the association of history of cardiovascular disease (CVD) with occurrence and severity of PD, here, we lend data on the association of CVD history with the frequency and the occurrence of idiopathic PD (iPD) using data from the Luxembourg Parkinson’s study (iPD n = 676 patients and non-PD n = 874 controls).

Results

We report that patients with a history of CVD are at high risk of developing iPD (odds ratio; OR = 1.56, 95% confidence interval; CI 1.09–2.08). This risk is stronger in males and remains significant after adjustment with confounders (OR 1.55, 95% CI 1.05–2.30). This increased susceptibility to iPD is linked to the severity of iPD symptoms mainly the non-motor symptoms of daily living (MDS-UPDRS I) and motor complications (MDS-UPDRS IV) in the affected individuals.

Conclusion

Individuals with history of CVD have a high risk of developing severe forms of iPD. This observation suggests that careful monitoring and management of patients with a history of cardiac problems may reduce the burden of iPD.