Scholarlink

Background <p>With the continuous escalation of resistance of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> to first line antibiotics such as colistin (COL), the development of novel therapeutic strategies is urgently required.</p> Results <p>This study demonstrates for the first time that 7-hydroxyflavone (7-HF) can restore COL’s bactericidal activity against clinically resistant <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i>, and the synergistic effect of 7-HF combined with COL was confirmed by both checkerboard and time-kill curves. The anti-biofilm effect of COL combined with 7-HF was evaluated by biofilm inhibition assay. Safety assessments, including cytotoxicity and erythrocyte hemolysis tests, indicated that both monotherapy and combination regimens were well-tolerated. In addition, the combined use of COL and 7-HF reduced the bacterial load in a mouse thigh infection model.</p> Conclusions <p>Our findings may provide a clinically safe and effective strategy for combating multidrug-resistant <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> infections.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Combination of 7-hydroxyflavone and colistin: antibacterial activity and mechanism against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月6日

查看全文
  • Mengjie Wei,
  • Ziyue Zeng,
  • Fan Ye,
  • Xiaowei Lv,
  • Zhuocheng Yao,
  • Deyi Zhao,
  • Tieli Zhou,
  • Lijiang Chen

摘要

Background

With the continuous escalation of resistance of Pseudomonas aeruginosa and Acinetobacter baumannii to first line antibiotics such as colistin (COL), the development of novel therapeutic strategies is urgently required.

Results

This study demonstrates for the first time that 7-hydroxyflavone (7-HF) can restore COL’s bactericidal activity against clinically resistant Pseudomonas aeruginosa and Acinetobacter baumannii, and the synergistic effect of 7-HF combined with COL was confirmed by both checkerboard and time-kill curves. The anti-biofilm effect of COL combined with 7-HF was evaluated by biofilm inhibition assay. Safety assessments, including cytotoxicity and erythrocyte hemolysis tests, indicated that both monotherapy and combination regimens were well-tolerated. In addition, the combined use of COL and 7-HF reduced the bacterial load in a mouse thigh infection model.

Conclusions

Our findings may provide a clinically safe and effective strategy for combating multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infections.