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Background <p>To characterize the dysbiosis of salivary microbiota in Saudi adults with periodontitis and identify potential population-specific microbial signatures.</p> Methods <p>Saliva samples were collected from 96 Saudi adults, including 50 patients with periodontitis and 46 control individuals. Microbiota profiling was performed using 16&#xa0;S rRNA gene sequencing (V3–V4 regions), followed by QIIME2-based bioinformatics and LEfSe analysis to determine diversity and differentially abundant taxa.</p> Results <p>Significant microbial dysbiosis was observed in the periodontitis group, characterized by higher Shannon diversity and altered community composition. A number of bacterial taxa were enriched specifically in Saudi patients with periodontitis, including <i>Leptotrichia</i>, <i>Acholeplasma</i>, and <i>Rothia dentocariosa</i>—taxa rarely emphasized in global studies. Other enriched taxa included <i>Filifactor</i>, <i>Selenomonas</i>, and <i>Prevotella intermedia</i>. In contrast, control individuals had higher levels of <i>Streptococcus</i>, <i>Granulicatella</i>, and <i>Neisseria oralis</i>. These patterns suggest the presence of regional microbial signatures.</p> Conclusions <p>This study reveals distinct salivary microbiota dysbiosis in Saudi adults with periodontitis and highlights unique taxa potentially linked to local environmental, dietary, or genetic factors. These findings support the need for population-specific microbial studies to inform personalized periodontal diagnostics and treatment.</p>

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Population-specific dysbiosis of the salivary microbiota in Saudi adults with periodontitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月13日

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  • Turki S. Abujamel,
  • Shaima M. Alhazmi,
  • Motaz Assas,
  • Mushref B. Assas,
  • Nadine Moubayed,
  • Munerah S. BinShabaib,
  • Shatha Subhi ALHarthi,
  • Kawther Aabed

摘要

Background

To characterize the dysbiosis of salivary microbiota in Saudi adults with periodontitis and identify potential population-specific microbial signatures.

Methods

Saliva samples were collected from 96 Saudi adults, including 50 patients with periodontitis and 46 control individuals. Microbiota profiling was performed using 16 S rRNA gene sequencing (V3–V4 regions), followed by QIIME2-based bioinformatics and LEfSe analysis to determine diversity and differentially abundant taxa.

Results

Significant microbial dysbiosis was observed in the periodontitis group, characterized by higher Shannon diversity and altered community composition. A number of bacterial taxa were enriched specifically in Saudi patients with periodontitis, including Leptotrichia, Acholeplasma, and Rothia dentocariosa—taxa rarely emphasized in global studies. Other enriched taxa included Filifactor, Selenomonas, and Prevotella intermedia. In contrast, control individuals had higher levels of Streptococcus, Granulicatella, and Neisseria oralis. These patterns suggest the presence of regional microbial signatures.

Conclusions

This study reveals distinct salivary microbiota dysbiosis in Saudi adults with periodontitis and highlights unique taxa potentially linked to local environmental, dietary, or genetic factors. These findings support the need for population-specific microbial studies to inform personalized periodontal diagnostics and treatment.