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<p>Ulcerative colitis (UC) is an intestinal disease caused by many factors that seriously harms the health of humans and animals. Probiotics are currently widely used to treat intestinal inflammation; however, different strains are specific, and the functions and effects of different strains are still unclear. In this study, <i>Lacticaseibacillus rhamnosus</i> G7 isolated from herdsmen yogurt was used. The results of the in vitro evaluation revealed that it had good tolerance and safety. In mice with colitis, G7 alleviated weight loss and colon shortening and reduced the DAI score. After G7 treatment, the levels of proinflammatory factors (IL-1β, IL-6 and TNF-α) and histopathological scores decreased, whereas the level of IL-10 increased. In addition, G7 rebalanced the intestinal microbial composition of colitis model mice by increasing the abundance of <i>Faecalibaculum</i> and decreasing the abundance of <i>Bacteroides</i> and <i>Escherichia_Shigella</i>. In summary, G7 has great potential in the prevention of colitis.</p>

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Lacticaseibacillus rhamnosus G7 alleviates DSS-induced ulcerative colitis by regulating the intestinal microbiota

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月26日

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  • Jianlong Lao,
  • Man Chen,
  • Shuping Yan,
  • Han Gong,
  • Zhaohai Wen,
  • Yanhong Yong,
  • Dan Jia,
  • Shuting Lv,
  • Wenli Zou,
  • Junmei Li,
  • Huiming Tan,
  • Hong Yin,
  • Xiangying Kong,
  • Zengyuan Liu,
  • Fucheng Guo,
  • Xianghong Ju,
  • Youquan Li

摘要

Ulcerative colitis (UC) is an intestinal disease caused by many factors that seriously harms the health of humans and animals. Probiotics are currently widely used to treat intestinal inflammation; however, different strains are specific, and the functions and effects of different strains are still unclear. In this study, Lacticaseibacillus rhamnosus G7 isolated from herdsmen yogurt was used. The results of the in vitro evaluation revealed that it had good tolerance and safety. In mice with colitis, G7 alleviated weight loss and colon shortening and reduced the DAI score. After G7 treatment, the levels of proinflammatory factors (IL-1β, IL-6 and TNF-α) and histopathological scores decreased, whereas the level of IL-10 increased. In addition, G7 rebalanced the intestinal microbial composition of colitis model mice by increasing the abundance of Faecalibaculum and decreasing the abundance of Bacteroides and Escherichia_Shigella. In summary, G7 has great potential in the prevention of colitis.