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Background <p>Inflammatory cytokines influence the pathogenesis and progression of acute myeloid leukaemia (AML), not only by shaping the leukemic microenvironment, but also by supporting leukaemia stem cell survival and resistance to therapy. We, therefore, investigated the associations between the cytokine polymorphisms <i>IFNG</i>+874&#xa0;A/T, <i>TNFA</i>−857&#xa0;C/T, and <i>IL1B</i> -31&#xa0;C/T and AML outcomes, as well as their influence on clinical features.</p> Results <p>Ninety-three patients with AML and 117 healthy controls were analysed. The T allele of <i>TNFA</i> − 857&#xa0;C/T (i.e., the high-expression allele) was observed at a significantly higher frequency in the patients with AML vs. the controls (AML vs. control = 24.7% vs. 16.2%, <i>p</i> = 0.04). Patients with the high-expression TT genotype had shorter overall survival (TT vs. CC = 46.0 vs. 224.1 months, <i>p</i> &lt; 0.001). Patients with the high-expression non-CC genotype relapsed more frequently than those with the low-expression CC genotype (relapse vs. non-relapse = 55.8% vs. 26.9%, <i>p</i> = 0.01). No significant associations were observed for the <i>IFNG</i> + 874&#xa0;A/T and <i>IL1B</i> -31&#xa0;C/T polymorphism.</p> Conclusion <p><i>TNFA</i> − 857&#xa0;C/T polymorphisms can influence patient susceptibility to AML, as well as its prognosis. This suggests a link between chronic inflammation and leukemogenesis, as well as the potential value of <i>TNFA</i> genotyping in risk assessments.</p>

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Prognostic significance of inflammatory cytokine polymorphisms in AML: a study of IFNG, TNFA, and IL1B polymorphisms

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月2日

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  • Tsatsralgerel Munkh-Erdene,
  • Takayuki Saitoh,
  • Miri Kitamura,
  • Asumi Kojima,
  • Takafumi Okawa,
  • Tsukasa Oda,
  • Eiji Miyauchi,
  • Nobuo Sasaki,
  • Ikuko Matsumura,
  • Akira Matsumoto,
  • Hisashi Takei,
  • Nobuhiko Kobayashi,
  • Yuri Miyazawa,
  • Yoshiyuki Ogawa,
  • Hiroshi Handa,
  • Nanami Gotoh

摘要

Background

Inflammatory cytokines influence the pathogenesis and progression of acute myeloid leukaemia (AML), not only by shaping the leukemic microenvironment, but also by supporting leukaemia stem cell survival and resistance to therapy. We, therefore, investigated the associations between the cytokine polymorphisms IFNG+874 A/T, TNFA−857 C/T, and IL1B -31 C/T and AML outcomes, as well as their influence on clinical features.

Results

Ninety-three patients with AML and 117 healthy controls were analysed. The T allele of TNFA − 857 C/T (i.e., the high-expression allele) was observed at a significantly higher frequency in the patients with AML vs. the controls (AML vs. control = 24.7% vs. 16.2%, p = 0.04). Patients with the high-expression TT genotype had shorter overall survival (TT vs. CC = 46.0 vs. 224.1 months, p < 0.001). Patients with the high-expression non-CC genotype relapsed more frequently than those with the low-expression CC genotype (relapse vs. non-relapse = 55.8% vs. 26.9%, p = 0.01). No significant associations were observed for the IFNG + 874 A/T and IL1B -31 C/T polymorphism.

Conclusion

TNFA − 857 C/T polymorphisms can influence patient susceptibility to AML, as well as its prognosis. This suggests a link between chronic inflammation and leukemogenesis, as well as the potential value of TNFA genotyping in risk assessments.