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<p>Super enhancers (SEs) are crucial regulatory elements in the genome that determine cell identity and fate commitment through mechanisms such as recruiting transcription factors (TFs), interacting with super enhancers RNAs (seRNAs), and phase separation. This ensures accurate gene expression in response to both environmental and intrinsic signals. Advances in 3D genome architecture have further illuminated how SEs are organized and regulated within the nucleus, thereby enhancing our understanding of their function. Recent innovations in genomic technologies, including chromatin accessibility, CRISPR-Cas9, 3&#xa0;C-based methods and imaging methods, have revolutionized the study of SEs. These technologies have facilitated precise mapping and functional characterization, providing deeper insights into how SEs influence gene regulation. In particular, these advancements offer promising potential for exploring SE dynamics in livestock improvement, opening avenues for the enhancement of agricultural and breeding practices.</p> Graphical abstract <p>An integrated overview of super-enhancer mechanisms, research technologies, and applications in livestock breeding.</p> <p></p>

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Understanding super enhancers in genome architecture and their roles in livestock breeding

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月12日

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  • Jie Cheng,
  • Xiukai Cao,
  • Kai Yang,
  • Yuee Gao,
  • Zexuan Hong,
  • Xudong Tang,
  • Ping Qian,
  • Bizhi Huang

摘要

Super enhancers (SEs) are crucial regulatory elements in the genome that determine cell identity and fate commitment through mechanisms such as recruiting transcription factors (TFs), interacting with super enhancers RNAs (seRNAs), and phase separation. This ensures accurate gene expression in response to both environmental and intrinsic signals. Advances in 3D genome architecture have further illuminated how SEs are organized and regulated within the nucleus, thereby enhancing our understanding of their function. Recent innovations in genomic technologies, including chromatin accessibility, CRISPR-Cas9, 3 C-based methods and imaging methods, have revolutionized the study of SEs. These technologies have facilitated precise mapping and functional characterization, providing deeper insights into how SEs influence gene regulation. In particular, these advancements offer promising potential for exploring SE dynamics in livestock improvement, opening avenues for the enhancement of agricultural and breeding practices.

Graphical abstract

An integrated overview of super-enhancer mechanisms, research technologies, and applications in livestock breeding.