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Background <p>The use of probiotics is increasingly popular for health applications, and <i>Lactiplantibacillus plantarum</i> strains are among the most widely studied for their potential in promoting gut health. In this study, we present the first genomic characterization of <i>L. plantarum</i> IGMA4EH, isolated from the gut of the maguey worm (<i>Aegiale hesperiaris</i>), an edible insect with traditional significance in Mexico.</p> Methodology <p>Whole-genome sequencing was performed on the <i>L. plantarum</i> IGMA4EH strain. Bioinformatics analyses were conducted to identify probiotic-related genes, antimicrobial potential, and safety features. Genes associated with resistance to environmental stressors, adhesion, and immunomodulation were screened, and safety assessment included the detection of antibiotic resistance genes, virulence factors, and plasmids.</p> Results <p>The genomic analysis revealed the presence of multiple probiotic-related genes, including those associated with resistance to temperature, acidity, oxidative stress, and bile. Additionally, gene clusters related to bacteriocins, and secondary metabolites were identified, suggesting strong antimicrobial potential. Safety evaluations showed no evidence of acquired antibiotic resistance genes, virulence factors, or plasmids. Furthermore, elements related to genetic stability, such as CRISPR-Cas systems and prophage regions, were also detected.</p> Conclusions <p>The findings highlight the potential of <i>L. plantarum</i> IGMA4EH as a novel probiotic strain with promising applications.</p>

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Genome sequencing analysis reveals probiotic potential of Lactiplantibacillus plantarum IGMA4EH isolated from the gut of the white maguey worm (Aegiale hesperiaris)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月28日

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  • Ericka Denice Herrera-Cardoso,
  • Karen Alejandra Tapia-Cervantes,
  • Jonathan Cepeda-Negrete,
  • Santiago Gutiérrez-Vargas,
  • Ma. Fabiola León-Galván

摘要

Background

The use of probiotics is increasingly popular for health applications, and Lactiplantibacillus plantarum strains are among the most widely studied for their potential in promoting gut health. In this study, we present the first genomic characterization of L. plantarum IGMA4EH, isolated from the gut of the maguey worm (Aegiale hesperiaris), an edible insect with traditional significance in Mexico.

Methodology

Whole-genome sequencing was performed on the L. plantarum IGMA4EH strain. Bioinformatics analyses were conducted to identify probiotic-related genes, antimicrobial potential, and safety features. Genes associated with resistance to environmental stressors, adhesion, and immunomodulation were screened, and safety assessment included the detection of antibiotic resistance genes, virulence factors, and plasmids.

Results

The genomic analysis revealed the presence of multiple probiotic-related genes, including those associated with resistance to temperature, acidity, oxidative stress, and bile. Additionally, gene clusters related to bacteriocins, and secondary metabolites were identified, suggesting strong antimicrobial potential. Safety evaluations showed no evidence of acquired antibiotic resistance genes, virulence factors, or plasmids. Furthermore, elements related to genetic stability, such as CRISPR-Cas systems and prophage regions, were also detected.

Conclusions

The findings highlight the potential of L. plantarum IGMA4EH as a novel probiotic strain with promising applications.