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Background <p>Enhancing bone quality is crucial for the health and productivity of laying hens. Fasting is a known way to cause physiological changes in layer hens, but research on skeletal changes during molting is still limited.</p> Results <p>This study used a fasting-induced model to assess phenotypic changes and systematically investigate bone resorption and remodeling through transcriptomic analysis. During this process, serum phosphorus, ALP, PTH, and E2 levels in the resumption of feeding were significantly higher than in other groups, with BMC in the resumption of feeding also being significantly elevated. Further transcriptome sequencing of the tibia at different periods was conducted, and many differentially expressed genes, such as <i>CCK</i>, <i>SHH</i>, <i>ENDRB</i>, <i>FZD4</i>, <i>AGT</i>, and <i>TRPM1</i>, were identified. Key signaling pathways involved in bone development, such as the Wnt/β-catenin and calcium signaling pathways, were also determined.</p> Conclusion <p>This adaptive response of fasting followed by refeeding helps improve bone quality in laying hens during the late laying period.</p>

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Effect of induced molting on bone remodeling in laying hens

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月22日

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  • Lujie Zhang,
  • Zhiyuan An,
  • Wei Li,
  • Xinxin Liu,
  • Enyou Zhou,
  • Peng Cui,
  • Yanhua Zhang,
  • Yujie Guo,
  • Guoxi Li,
  • Zhuanjian Li,
  • Yadong Tian,
  • Shucheng Huang,
  • Ruirui Jiang,
  • Xiangtao Kang,
  • Ruili Han

摘要

Background

Enhancing bone quality is crucial for the health and productivity of laying hens. Fasting is a known way to cause physiological changes in layer hens, but research on skeletal changes during molting is still limited.

Results

This study used a fasting-induced model to assess phenotypic changes and systematically investigate bone resorption and remodeling through transcriptomic analysis. During this process, serum phosphorus, ALP, PTH, and E2 levels in the resumption of feeding were significantly higher than in other groups, with BMC in the resumption of feeding also being significantly elevated. Further transcriptome sequencing of the tibia at different periods was conducted, and many differentially expressed genes, such as CCK, SHH, ENDRB, FZD4, AGT, and TRPM1, were identified. Key signaling pathways involved in bone development, such as the Wnt/β-catenin and calcium signaling pathways, were also determined.

Conclusion

This adaptive response of fasting followed by refeeding helps improve bone quality in laying hens during the late laying period.