Scholarlink

Background <p><i>Staphylococcus epidermidis</i> (<i>Se</i>) is commonly regarded as a commensal organism; however, under specific conditions, it may act as an opportunistic pathogen. Here, we report the whole-genome sequencing and comparative genomic analysis of <i>Se</i> strain 252 (<i>Se252</i>), isolated from the rhizosphere of an endemic Brazilian plant.</p> Results <p><i>Se252</i> exhibits a unique repertoire of genes associated with environmental adaptation and virulence. These include two putative Type VII secretion system (T7SS) effectors and thirteen proteins involved in adhesion, toxin production, and immune evasion—among them, IsaB, which has not been previously reported in <i>Se</i>. Gene family expansions were observed in loci related to phenol-soluble modulins (PSMs), TLpps, LPXTG-motif proteins, nonribosomal peptide synthetases (NRPS), and siderophore biosynthesis (staphylopine, staphyloferrin), as well as quorum-sensing autoinducing peptides. In contrast, <i>Se252</i> harbors relatively few antibiotic resistance genes.</p> Conclusions <p>The genomic profile of <i>Se252</i> reflects adaptations to a plant-associated environment, yet harbors multiple features potentially enhancing human pathogenicity. These findings highlight the relevance of environmental <i>Se</i> lineages as possible reservoirs of virulence traits with implications for public health.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Genomic characterization of Staphylococcus epidermidis Se252 isolated from the rhizosphere of a Brazilian endemic plant

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月31日

查看全文
  • Angélica Bianchini Sanchez,
  • Camila Gracyelle de Carvalho Lemes,
  • Isabella Ferreira Cordeiro,
  • Washington Luiz Caneschi,
  • Érica Felestrino Barbosa ,
  • Camila Henriques de Paula,
  • Ana Karla da Silva,
  • Dilson Fagundes Ribeiro,
  • Rosilene Cristina de Matos,
  • Jéssica Pereira de Matos,
  • Lorrana Cachuite Mendes Rocha,
  • Maria Rosilene Alves Damasceno,
  • Camila Carrião Machado Garcia,
  • João Carlos Setubal,
  • Alessandro de Mello Varani,
  • Nalvo Franco Almeida,
  • Leandro Marcio Moreira

摘要

Background

Staphylococcus epidermidis (Se) is commonly regarded as a commensal organism; however, under specific conditions, it may act as an opportunistic pathogen. Here, we report the whole-genome sequencing and comparative genomic analysis of Se strain 252 (Se252), isolated from the rhizosphere of an endemic Brazilian plant.

Results

Se252 exhibits a unique repertoire of genes associated with environmental adaptation and virulence. These include two putative Type VII secretion system (T7SS) effectors and thirteen proteins involved in adhesion, toxin production, and immune evasion—among them, IsaB, which has not been previously reported in Se. Gene family expansions were observed in loci related to phenol-soluble modulins (PSMs), TLpps, LPXTG-motif proteins, nonribosomal peptide synthetases (NRPS), and siderophore biosynthesis (staphylopine, staphyloferrin), as well as quorum-sensing autoinducing peptides. In contrast, Se252 harbors relatively few antibiotic resistance genes.

Conclusions

The genomic profile of Se252 reflects adaptations to a plant-associated environment, yet harbors multiple features potentially enhancing human pathogenicity. These findings highlight the relevance of environmental Se lineages as possible reservoirs of virulence traits with implications for public health.

Graphical Abstract