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LCRAnnotationsDB: a database of low complexity regions functional and structural annotations

  • Joanna Ziemska-Legiecka,
  • Patryk Jarnot,
  • Sylwia Szymańska,
  • Dagmara Błaszczyk,
  • Alicja Staśczak,
  • Hanna Langer-Macioł,
  • Kinga Lucińska,
  • Karolina Widzisz,
  • Aleksandra Janas,
  • Hanna Słowik,
  • Wiktoria Śliwińska,
  • Aleksandra Gruca,
  • Marcin Grynberg

摘要

Low Complexity Regions (LCRs) are segments of proteins with a low diversity of amino acid composition. These regions play important roles in proteins. However, annotations describing these functions are dispersed across databases and scientific literature. LCRAnnotationsDB aims to consolidate knowledge about LCRs and store relevant annotations in a single place. To unify redundant annotations, we assigned them categories based on similarity in function, protein structure, and biological process. Categories are organized hierarchically by linking them to Gene Ontology terms. The LCRAnnotationsDB database can be accessed at https://lcrannotdb.lcr-lab.org/.