Scholarlink

Background <p>In the early vertebrate history, gene duplications, including single-gene, segmental-gene (SSD), and whole-genome duplication (WGD), formed multigene families. Despite efforts to classify metazoan multigene families hierarchically for evolutionary insight, a gap exists in accessible, curated resources for human/vertebrate multigene families.</p> Results <p>Addressing this, we present the Phylogenomic Analysis of Human Genome (PAHG) database. It focuses on curated multigene families in the human genome, particularly within four paralogons: HOX-bearing (Hsa:2/7/12/17), FGFR-bearing (Hsa:4/5/8/10), MHC-bearing (Hsa:1/6/9/19), and chromosomes 1/2/8/20.</p> Conclusion <p>The current PAHG version details the phylogenetic history of 221 human multigene families (1247 gene members) with 15,231 protein sequences from diverse metazoans. It provides insights into gene duplication timings, co-duplication events, and their relationships with human genome syntenic organization. The PAHG database addresses the lack of accessible resources, offering valuable information on human/vertebrate multigene family evolution. Access the PAHG database at: <a href="https://www.pahgncb.com/">https://www.pahgncb.com/</a> and <a href="http://pahg.qau.edu.pk/">http://pahg.qau.edu.pk/</a>. This resource enriches our understanding of vertebrate genetic evolution.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

PAHG: the database of human multi-gene families

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月14日

查看全文
  • Ramsha Azhar,
  • Muhammad Faizan Malik,
  • Rozeena Arif,
  • Muhammad Waqas Khokhar,
  • Yasir Mehmood Abbasi,
  • Fatima Batool,
  • Muhammad Haseeb Jalalzai,
  • Yiming Bao,
  • Amir Ali Abbasi

摘要

Background

In the early vertebrate history, gene duplications, including single-gene, segmental-gene (SSD), and whole-genome duplication (WGD), formed multigene families. Despite efforts to classify metazoan multigene families hierarchically for evolutionary insight, a gap exists in accessible, curated resources for human/vertebrate multigene families.

Results

Addressing this, we present the Phylogenomic Analysis of Human Genome (PAHG) database. It focuses on curated multigene families in the human genome, particularly within four paralogons: HOX-bearing (Hsa:2/7/12/17), FGFR-bearing (Hsa:4/5/8/10), MHC-bearing (Hsa:1/6/9/19), and chromosomes 1/2/8/20.

Conclusion

The current PAHG version details the phylogenetic history of 221 human multigene families (1247 gene members) with 15,231 protein sequences from diverse metazoans. It provides insights into gene duplication timings, co-duplication events, and their relationships with human genome syntenic organization. The PAHG database addresses the lack of accessible resources, offering valuable information on human/vertebrate multigene family evolution. Access the PAHG database at: https://www.pahgncb.com/ and http://pahg.qau.edu.pk/. This resource enriches our understanding of vertebrate genetic evolution.