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Background <p>Respiratory Syncytial Virus (RSV) is a major cause of acute respiratory tract infections (ARTI) worldwide, with seasonal outbreaks often influenced by climatic factors. This study investigates the genetic diversity and phylogenetic relationships of RSV strains circulated in Sri Lanka between 2022 December and 2024 February.</p> Results <p>Subtyping of 12 RSV-positive samples identified both RSV A and B, with full-length F gene sequences obtained for four samples. Phylogenetic analysis revealed clustering with globally circulating strains. Mutation profiling highlighted key amino acid substitutions, including a rare mutation of N116D in the F protein, which may have functional implications. The limited sample size necessitates further studies with broader geographic coverage for more robust conclusions.</p> Conclusion <p>This study provides insights into the genetic diversity of RSV F gene in Sri Lanka.</p>

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Genomic characterization and phylogenetic analysis of respiratory syncytial virus F gene in Sri Lanka: a comparative study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月29日

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  • Thejanee Perera,
  • Ishani De Silva,
  • Pavithri Bandara,
  • Asanka Bowatte,
  • Dinithi Rathnayake,
  • Shanika Perera,
  • Saranga Sumathipala,
  • Rohitha Muthugala

摘要

Background

Respiratory Syncytial Virus (RSV) is a major cause of acute respiratory tract infections (ARTI) worldwide, with seasonal outbreaks often influenced by climatic factors. This study investigates the genetic diversity and phylogenetic relationships of RSV strains circulated in Sri Lanka between 2022 December and 2024 February.

Results

Subtyping of 12 RSV-positive samples identified both RSV A and B, with full-length F gene sequences obtained for four samples. Phylogenetic analysis revealed clustering with globally circulating strains. Mutation profiling highlighted key amino acid substitutions, including a rare mutation of N116D in the F protein, which may have functional implications. The limited sample size necessitates further studies with broader geographic coverage for more robust conclusions.

Conclusion

This study provides insights into the genetic diversity of RSV F gene in Sri Lanka.