Induction of chronic asthma up regulated the transcription of senile factors in male rats

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2024年10月18日

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Majid Hassanzadeh-Khanmiri,
Rana Keyhanmanesh,
Reza Mosaddeghi-Heris,
Aref Delkhosh,
Jafar Rezaie,
Sajjad Taghizadeh,
Mehdi Rezai Seghin Sara,
Mahdi Ahmadi

摘要

Background

The main characteristic of asthma is chronic inflammation. We examined cellular senescence by histology and molecular assay in the lungs of a rat model of asthma. This model comprises sensitization by several intraperitoneal injections of ovalbumin with aluminium hydroxide, followed by aerosol challenges every other day.

Results

Data showed that asthma induction caused histological changes including, hyperemia, interstitial pneumonia, fibrinogen clots, and accumulation of inflammatory cells in the pleura. There is an elevation of IL-1β and NF-kB proteins in the asthmatic group (P < 0.001) compared to the control group. The expression of ß-galactosidase increased (P < 0.01), while the expression of Klotho and Sox2 genes was decreased in the lung tissue of the asthmatic group (P < 0.01).

Conclusion

Taken together, these findings suggest that asthmatic conditions accelerated the cellular senescence in the lung tissue.