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Purpose <p>To present a case of recurrent uveitic macular edema (UME) treated with intravitreal faricimab injection.</p> Methods <p>Single case report from a tertiary referral center.</p> Observations <p>A 63-year-old Caucasian female presenting with recurrent UME due to birdshot chorioretinopathy (BSCR) in both eyes. UME had been treated with multiple agents including intravenous methylprednisone, posterior subtenons and intravitreal triamcinolone acetonide injection, dexamethasone implant, mycophenolate mofetil, and adalimumab with limited improvement and development of intolerance. Moreover, optical coherence tomography also revealed recurrence of UME with subretinal fluid in both eyes. After treatment with one dose of intravitreal faricimab injection, complete resolution of UME was achieved and maintained for three months.</p> Conclusion <p>The findings of this case hint towards the potential simultaneous effect of angiopoietin-2 blockade along with vascular endothelia growth factor A inhibition by faricimab in managing treatment-resistant UME. Nonetheless, more studies focusing on the role of intravitreal faricimab in UME are required.</p>

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Recurrent uveitic macular edema managed with intravitreal faricimab injection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月13日

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  • Negin Yavari,
  • Dalia El Feky,
  • Frances A. Anover,
  • Khiem Nguyen,
  • Azadeh Mobasserian,
  • Quan Dong Nguyen,
  • Christopher Or

摘要

Purpose

To present a case of recurrent uveitic macular edema (UME) treated with intravitreal faricimab injection.

Methods

Single case report from a tertiary referral center.

Observations

A 63-year-old Caucasian female presenting with recurrent UME due to birdshot chorioretinopathy (BSCR) in both eyes. UME had been treated with multiple agents including intravenous methylprednisone, posterior subtenons and intravitreal triamcinolone acetonide injection, dexamethasone implant, mycophenolate mofetil, and adalimumab with limited improvement and development of intolerance. Moreover, optical coherence tomography also revealed recurrence of UME with subretinal fluid in both eyes. After treatment with one dose of intravitreal faricimab injection, complete resolution of UME was achieved and maintained for three months.

Conclusion

The findings of this case hint towards the potential simultaneous effect of angiopoietin-2 blockade along with vascular endothelia growth factor A inhibition by faricimab in managing treatment-resistant UME. Nonetheless, more studies focusing on the role of intravitreal faricimab in UME are required.