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Background <p>To study the utility of interferon gamma (IFN-γ) as a differentiating biomarker by assessing the aqueous humour and serum of patients with infectious and noninfectious uveitis.</p> Methods <p>A total of 40 patients with acute uveitis were divided into 2 groups (18 patients with infectious uveitis and 22 patients with noninfectious uveitis). All the subjects underwent a full ophthalmological examination. Aqueous humour (AqH) and serum samples were collected from uveitis patients. The quantitative levels of IFN-γ in aqueous medium and serum were measured by means of an enzyme-linked immunosorbent assay (ELISA).</p> Results <p>The quantitative level of IFN-γ in the aqueous humour was significantly greater (87.5 ± 81) (pg/ml) in infectious uveitis patients than in noninfectious uveitis patients (37.3 ± 9.9) (pg/ml) (<i>p</i> value = 0.006). However, the serum IFN-γ level (pg/ml) did not significantly differ between these groups (<i>p</i> value = 0.279). Thus, the IFN-γ level in the aqueous humour can be used to discriminate between infectious and noninfectious uveitis with 33.3% sensitivity and 100% specificity.</p> Conclusion <p>Aqueous IFN-γ can be used as a biomarker for differentiating between infectious and noninfectious uveitis.</p>

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Quantitative levels of interferon gamma as a biomarker in the aqueous and serum samples of infectious and noninfectious uveitis patients

  • 期刊论文

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  • 发表日期：

    2025年2月26日

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  • Sahar Saad Eldeen Mohamed Shaban,
  • Hend Mohammed Safwat,
  • Abeer Mohammed Abdelmohymen,
  • Donia Ahmed Hassan,
  • Mona Nabeh Mansour,
  • Hanan Said Mohammed,
  • Nora Seliem,
  • Shahinaz El Attar,
  • Doaa Refaat Amin,
  • Seham Kamal Ahmed Khirala,
  • Aya Ahmed Ghamry,
  • Mona Gamal El Din Al Anany,
  • Shaymaa Fathy Mohammed

摘要

Background

To study the utility of interferon gamma (IFN-γ) as a differentiating biomarker by assessing the aqueous humour and serum of patients with infectious and noninfectious uveitis.

Methods

A total of 40 patients with acute uveitis were divided into 2 groups (18 patients with infectious uveitis and 22 patients with noninfectious uveitis). All the subjects underwent a full ophthalmological examination. Aqueous humour (AqH) and serum samples were collected from uveitis patients. The quantitative levels of IFN-γ in aqueous medium and serum were measured by means of an enzyme-linked immunosorbent assay (ELISA).

Results

The quantitative level of IFN-γ in the aqueous humour was significantly greater (87.5 ± 81) (pg/ml) in infectious uveitis patients than in noninfectious uveitis patients (37.3 ± 9.9) (pg/ml) (p value = 0.006). However, the serum IFN-γ level (pg/ml) did not significantly differ between these groups (p value = 0.279). Thus, the IFN-γ level in the aqueous humour can be used to discriminate between infectious and noninfectious uveitis with 33.3% sensitivity and 100% specificity.

Conclusion

Aqueous IFN-γ can be used as a biomarker for differentiating between infectious and noninfectious uveitis.