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Background <p>Copper (Cu) toxicity induces intestinal mucosal damage in chickens. However, selenized-yeast (SY) is reported to enhance the general health and metabolic state of broiler chickens. Thus, this study was proposed to discover whether SY could protect chickens against Cu-induced intestinal damage. Healthy chicks were divided into 4 groups: Control group received basal diet; Cu group, received CuSO<sub>4</sub> at 300 mg/kg, SY group received 0.4 mg/kg, and SY plus CuSO<sub>4</sub> group received both treatments in diet.</p> Results <p>The current data indicated a significant reduction (<i>P</i> &lt; 0.05) in residual Cu levels and MDA levels with a substantial increase in (<i>P</i> &lt; 0.05) the activities of GPx, CAT, and SOD in the SY-supplemented birds compared to the Cu-challenged ones. Moreover, the reduced (<i>P</i> &lt; 0.05) NO levels and inflammatory markers affirming the anti-inflammatory role of SY. Besides, SY co-administration significantly (<i>P</i> &lt; 0.05) downregulated the AvBD-2, and AvBD-9 and upregulated (<i>P</i> &lt; 0.05) the Gastrotropin, Calbindin, Cath-B, and Muc2 mRNA expressions compared to Cu-intoxicated group. The histopathological findings validated the protective effect of SY on Cu-induced intestinal damage</p> Conclusion <p>Our research suggested that SY may be used as a feed supplement to protect the intestine injury during Cu exposure. This might be attributed to the antioxidant and anti-inflammatory potential of SY.</p>

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Selenium-enriched Saccharomyces cerevisiae ameliorated copper-induced intestinal damage by modulating inflammation, oxidative stress, and immune response genes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月4日

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  • Ola A. Habotta,
  • Ahmed Ateya,
  • Ehab S. Taher,
  • Nada M. Hashem,
  • Eman Gadu,
  • Eman S. El-Ashry,
  • Rehab Mady,
  • Samah F. Ibrahim,
  • Mohamed E. Mohamed,
  • Donia E. Zaghamir,
  • Heba Allah M. Elbaghdady,
  • Mohamed E. Salama,
  • Sally Y. Abed,
  • Rehab Morsi,
  • Dania Abdelhady,
  • Ahmad F. Rawan,
  • Ahmed Abdeen

摘要

Background

Copper (Cu) toxicity induces intestinal mucosal damage in chickens. However, selenized-yeast (SY) is reported to enhance the general health and metabolic state of broiler chickens. Thus, this study was proposed to discover whether SY could protect chickens against Cu-induced intestinal damage. Healthy chicks were divided into 4 groups: Control group received basal diet; Cu group, received CuSO4 at 300 mg/kg, SY group received 0.4 mg/kg, and SY plus CuSO4 group received both treatments in diet.

Results

The current data indicated a significant reduction (P < 0.05) in residual Cu levels and MDA levels with a substantial increase in (P < 0.05) the activities of GPx, CAT, and SOD in the SY-supplemented birds compared to the Cu-challenged ones. Moreover, the reduced (P < 0.05) NO levels and inflammatory markers affirming the anti-inflammatory role of SY. Besides, SY co-administration significantly (P < 0.05) downregulated the AvBD-2, and AvBD-9 and upregulated (P < 0.05) the Gastrotropin, Calbindin, Cath-B, and Muc2 mRNA expressions compared to Cu-intoxicated group. The histopathological findings validated the protective effect of SY on Cu-induced intestinal damage

Conclusion

Our research suggested that SY may be used as a feed supplement to protect the intestine injury during Cu exposure. This might be attributed to the antioxidant and anti-inflammatory potential of SY.