Background <p>The current study aims to evaluate the impact of the iodixanol contrast agent used in intravenous urography (IVU) on the displacement or treatment of ureteral stones.</p> Materials and methods <p>In this clinical trial, patients presenting with flank pain and symptoms of renal colic who were referred to the Urology Clinic of Shahid Beheshti Hospital in Hamedan, Iran, during the years 2020 to 2021 were included. After examination, request for ultrasound, kidney ureter bladder (KUB), and confirmation of opaque ureteral stone, they were randomly (by lottery method) divided into two groups: case (IVU using iodixanol) and control. Then, the stone site and expulsion results were compared in both groups. This study was registered on the Iranian Registry of Clinical Trial Database (IRCTID) (code: IRCT20200616047796N1).</p> Results <p>One hundred and seventeen (<i>N</i> = 117) patients with ureteral stones participated in this research. The mean age of patients was 38.13 ± 10.47 years. The stone expulsion rate was 22% in the intervention group compared to 5.2% in the control group (<i>P</i> = .008). The intervention group had a stone displacement percentage of 34.80%, compared to 5.20% in the control group (<i>P</i> = .047). This demonstrates the significant effect of this method on stone expulsion and displacement.</p> Conclusion <p>The results demonstrated that IVU significantly affected stone expulsion and displacement.</p>