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Background <p>Erectile dysfunction is a common condition often resistant to single-drug treatments. This study evaluated whether adjunct celecoxib could enhance the effect of tadalafil on erectile function.</p> Methods <p>In this randomized controlled trial, 50&#xa0;men with moderate-to-severe erectile dysfunction were randomized to tadalafil 5&#xa0;mg plus celecoxib 200&#xa0;mg daily (intervention) or tadalafil 5 mg plus placebo (control) for 8&#xa0;weeks. Erectile function was assessed with the International Index of Erectile Function (IIEF) questionnaire.</p> Results <p>Of 50 randomized, 47 were analyzed (intervention <i>n</i> = 23; control <i>n</i> = 24). Post-treatment total IIEF scores were higher in the intervention group (18.04 ± 5.06) versus control (15.37 ± 3.59; <i>P</i> = 0.042), while the distribution of erectile-dysfunction severity categories did not differ significantly between groups.</p> Conclusions <p>The combination of tadalafil and celecoxib was associated with a statistically significant improvement in IIEF total scores compared with tadalafil alone. However, the distribution of ED-severity categories did not change significantly; the clinical implication of our findings derives from continuous score improvement rather than categorical transition.</p>

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Evaluation of the synergetic effect of celecoxib and tadalafil on erectile function in patients with erectile dysfunction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月21日

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  • Salman Soltani,
  • Amir Abbas Asadpour,
  • Alireza Akhavan Rezayat,
  • Seyed Mohammad Tavousi,
  • Maryam Emadzadeh,
  • Atena Aghaee,
  • Mohammad Ramezani

摘要

Background

Erectile dysfunction is a common condition often resistant to single-drug treatments. This study evaluated whether adjunct celecoxib could enhance the effect of tadalafil on erectile function.

Methods

In this randomized controlled trial, 50 men with moderate-to-severe erectile dysfunction were randomized to tadalafil 5 mg plus celecoxib 200 mg daily (intervention) or tadalafil 5 mg plus placebo (control) for 8 weeks. Erectile function was assessed with the International Index of Erectile Function (IIEF) questionnaire.

Results

Of 50 randomized, 47 were analyzed (intervention n = 23; control n = 24). Post-treatment total IIEF scores were higher in the intervention group (18.04 ± 5.06) versus control (15.37 ± 3.59; P = 0.042), while the distribution of erectile-dysfunction severity categories did not differ significantly between groups.

Conclusions

The combination of tadalafil and celecoxib was associated with a statistically significant improvement in IIEF total scores compared with tadalafil alone. However, the distribution of ED-severity categories did not change significantly; the clinical implication of our findings derives from continuous score improvement rather than categorical transition.