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Background <p>Loxoprofen, widely used as a nonsteroidal anti-inflammatory drug worldwide, is a prodrug that is converted to its active trans-hydroxylated metabolite. Reports of loxoprofen overdose are extremely limited, and asymptomatic cases despite massive ingestion have not been previously documented.</p> Case presentation <p>A 43-year-old woman ingested 8,280&#xa0;mg of loxoprofen. She arrived at the hospital two hours later in a clinically stable condition. Laboratory tests and electrocardiography were unremarkable, and abdominal computed tomography revealed no gastric contents. She remained asymptomatic, with normal laboratory findings throughout the hospitalisation period, and was discharged on day 3. Pharmacokinetic analysis using liquid chromatography–mass spectrometry revealed markedly elevated plasma concentrations of loxoprofen and its metabolites two hours after ingestion (loxoprofen 159&#xa0;µg/mL, trans-OH 64&#xa0;µg/mL, cis-OH 29&#xa0;µg/mL), which declined rapidly thereafter.</p> Conclusion <p>This case suggests that markedly elevated plasma concentrations of loxoprofen and its metabolites do not necessarily result in toxicity. Pharmacokinetic findings indicate that rapid metabolism may prevent organ damage.</p>

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Loxoprofen overdose without toxicity: pharmacokinetics of loxoprofen and metabolites analysed by liquid chromatography–mass spectrometry: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月29日

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  • Daiki Mori,
  • Jotaro Tachino,
  • Kazuo Harada,
  • Miyu Ueki,
  • Kensuke Minami,
  • Ryosuke Takegawa,
  • Tomoya Hirose,
  • Shota Nakao,
  • Hiroshi Matsumoto,
  • Jun Oda

摘要

Background

Loxoprofen, widely used as a nonsteroidal anti-inflammatory drug worldwide, is a prodrug that is converted to its active trans-hydroxylated metabolite. Reports of loxoprofen overdose are extremely limited, and asymptomatic cases despite massive ingestion have not been previously documented.

Case presentation

A 43-year-old woman ingested 8,280 mg of loxoprofen. She arrived at the hospital two hours later in a clinically stable condition. Laboratory tests and electrocardiography were unremarkable, and abdominal computed tomography revealed no gastric contents. She remained asymptomatic, with normal laboratory findings throughout the hospitalisation period, and was discharged on day 3. Pharmacokinetic analysis using liquid chromatography–mass spectrometry revealed markedly elevated plasma concentrations of loxoprofen and its metabolites two hours after ingestion (loxoprofen 159 µg/mL, trans-OH 64 µg/mL, cis-OH 29 µg/mL), which declined rapidly thereafter.

Conclusion

This case suggests that markedly elevated plasma concentrations of loxoprofen and its metabolites do not necessarily result in toxicity. Pharmacokinetic findings indicate that rapid metabolism may prevent organ damage.