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<p>Guillain-Barré Syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy, with several clinical variants including the acute motor axonal neuropathy (AMAN) subtype. AMAN often presents with rapid motor weakness, respiratory compromise, and may follow antecedent infections. We report a rare and severe case of AMAN in a 25-year-old female presenting with rapidly progressive quadriplegia and type II respiratory failure. She required prolonged mechanical ventilation, developed multiple hospital-acquired infections, and experienced infusion-related adverse reactions to intravenous immunoglobulin (IVIg). Despite these complications, gradual improvement was achieved through multidisciplinary care. This case underscores the potential severity of AMAN, especially when complicated by immunotherapy intolerance and secondary infections. It highlights the importance of early diagnosis, vigilant respiratory support, and individualised treatment strategies in improving outcomes in severe GBS variants.</p>

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A Guillain Barre Syndrome (GBS): a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月8日

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  • Sara Timerga,
  • Aynalem Befkadu

摘要

Guillain-Barré Syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy, with several clinical variants including the acute motor axonal neuropathy (AMAN) subtype. AMAN often presents with rapid motor weakness, respiratory compromise, and may follow antecedent infections. We report a rare and severe case of AMAN in a 25-year-old female presenting with rapidly progressive quadriplegia and type II respiratory failure. She required prolonged mechanical ventilation, developed multiple hospital-acquired infections, and experienced infusion-related adverse reactions to intravenous immunoglobulin (IVIg). Despite these complications, gradual improvement was achieved through multidisciplinary care. This case underscores the potential severity of AMAN, especially when complicated by immunotherapy intolerance and secondary infections. It highlights the importance of early diagnosis, vigilant respiratory support, and individualised treatment strategies in improving outcomes in severe GBS variants.