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Abstract <p>Atropine, a cholinergic receptor antagonist, counteracts the parasympathetic nervous system’s inhibitory effects on the sinus node, thereby increasing heart rate. It is frequently used to manage atrioventricular block, organophosphate and beta-blocker poisoning, and sinus bradycardia. This case report highlights a rare instance of hypertensive urgency induced by atropine administration, emphasizing the clinical significance of this adverse effect. We present a case report involving a 48-year-old male patient scheduled for right inguinal hernia surgery. The patient was administered atropine prior to the procedure and subsequently experienced severe hypertension and a headache, which were treated with labetalol. After 24&#xa0;h of monitoring, the patient was discharged without further complications. Documenting such cases is crucial for enhancing our understanding of atropine’s safety profile and refining management strategies to mitigate associated risks.</p> Clinical trial number <p>Not applicable.</p>

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Severe hypertension after atropine administration a case report:

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月24日

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  • Sara Timerga,
  • Aynalem Befkadu

摘要

Abstract

Atropine, a cholinergic receptor antagonist, counteracts the parasympathetic nervous system’s inhibitory effects on the sinus node, thereby increasing heart rate. It is frequently used to manage atrioventricular block, organophosphate and beta-blocker poisoning, and sinus bradycardia. This case report highlights a rare instance of hypertensive urgency induced by atropine administration, emphasizing the clinical significance of this adverse effect. We present a case report involving a 48-year-old male patient scheduled for right inguinal hernia surgery. The patient was administered atropine prior to the procedure and subsequently experienced severe hypertension and a headache, which were treated with labetalol. After 24 h of monitoring, the patient was discharged without further complications. Documenting such cases is crucial for enhancing our understanding of atropine’s safety profile and refining management strategies to mitigate associated risks.

Clinical trial number

Not applicable.