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<p>Plasmonic surface-enhanced Raman scattering (SERS) nanobiosensors employ nanoscale electromagnetic field amplification to achieve ultrasensitive, multiplex molecular detection. This review systematically outlines the fundamental plasmonic principles, nanostructure engineering strategies, and surface chemical functionalization approaches that dictate sensor performance. Quantitative analysis methodologies—including internal standards, ratio-based quantification, and machine learning-driven spectral interpretation—are critically examined. Potential clinical and field applications are highlighted through examples involving nucleic acids, proteins, pathogens, and environmental toxicants. Key technical challenges, such as reproducibility, scalable manufacturing, and methodological standardization, are discussed in detail. Finally, future directions are proposed, emphasizing single-molecule quantification, in vivo SERS applications, and the integration of sustainable materials into sensor design.</p>

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Plasmonic and surface-enhanced Raman nanobiosensors for quantitative molecular detection

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月2日

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  • Yeongbeom Kim,
  • Jaewon Choi,
  • Subin Lee,
  • Yerim Kim,
  • Jisu Park,
  • Kisung Lee,
  • Eunsoo Cho,
  • Jaewon Lee,
  • Kwang Suk Lim,
  • Hyun-Ouk Kim

摘要

Plasmonic surface-enhanced Raman scattering (SERS) nanobiosensors employ nanoscale electromagnetic field amplification to achieve ultrasensitive, multiplex molecular detection. This review systematically outlines the fundamental plasmonic principles, nanostructure engineering strategies, and surface chemical functionalization approaches that dictate sensor performance. Quantitative analysis methodologies—including internal standards, ratio-based quantification, and machine learning-driven spectral interpretation—are critically examined. Potential clinical and field applications are highlighted through examples involving nucleic acids, proteins, pathogens, and environmental toxicants. Key technical challenges, such as reproducibility, scalable manufacturing, and methodological standardization, are discussed in detail. Finally, future directions are proposed, emphasizing single-molecule quantification, in vivo SERS applications, and the integration of sustainable materials into sensor design.