<p>This study is conducted for the comparative analysis of unsteady magnetohydrodynamic flow and heat-mass transfer behaviour of two different hybrid nanofluids such as <i>TiO</i>_<i>2</i>, <i>Cu /</i>Water and <i>TiO</i>_<i>2</i>, <i>Cu /</i>Water + Ethylene glycol&#xa0;(50:50) over an inclined vertical porous plate subjected to uniform angled magnetic strength, thermal radiation, heat source/sink and coupled influence of Soret and Dufour effects. The flow is induced by buoyancy force, which is modelled using the nonlinear Boussinesq approximation. The equations that can govern the system are non-dimensionalized by using appropriate similarity transformations and dimensionless parameters. Multi regular Perturbation method is employed to get the solution. The various pertinent parameters involved in the system are considered for the analysis of their implications on the various profiles. The analysis of this study reveals that the velocity of the fluid is enhanced with higher values of permeability, buoyancy, Dufour and Soret parameters, whereas diminished with high values of magnetic field strength, magnetic field inclination, volume fraction of the nanoparticles and plate angle parameters. As the values of radiation, Dufour and volume fraction parameters increased, so does the temperature profile. Concentration profile is developed with high Soret number value. Moreover, the numerical values of engineering quantities, including the Skin friction coefficient and Nusselt number are presented in tabular form. The findings of this study are having applications relevant to microelectronics cooling, heat exchangers and battery thermal management systems.</p>