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Objectives <p>This work aims to develop a novel filler system by using resveratrol-loaded hollow mesoporous silica (HMS) to enhance the mechanical properties and reduce cytotoxicity of dental resin cement.</p> Materials &amp; Methods <p>HMS was synthesised via an ammonia-catalysed sol–gel process. Resveratrol (Res) was encapsulated by HMS to obtain Res@HMS. Res@HMS was characterised via transmission electron microscopy, dynamic light scattering, nitrogen adsorption/desorption measurements, fourier transform infrared spectroscopy and thermogravimetric analysis. An experimental resin cement containing Res@HMS was prepared. The mechanical properties of resin cement were measured, including flexural strength, elastic modulus and Shore hardness. The in vitro cytotoxicity of resin cement was evaluated via CCK8, lactate dehydrogenase assay and reactive oxygen species measurement.</p> Results <p>A Res@HMS filler system with hollow mesoporous structure and the ability to encapsulate large amounts of resveratrol was successfully synthesised. This experimental resin cement modified by Res@HMS exhibited remarkable mechanical properties, especially against thermocycling ageing. The introduction of Res@HMS effectively protected human gingival fibroblasts against resin monomer-induced cytotoxicity.</p> Conclusion <p>Res@HMS can serve as a versatile modifier to optimise dental resin cement. This modification can preserve the long-term mechanical properties of dental cement and also reduce resin monomer-induced cytotoxicity.</p> Clinical significance <p>The effective integration of mesoporous nanoparticles with plant extracts offers a novel filler that promises to balance the mechanical properties and cytotoxicity of resin cement, paving the way for developing a new generation of dental restorative materials.</p>

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Development of resveratrol-loaded hollow mesoporous silica enhances mechanical performance and biocompatibility of dental resin cement

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月10日

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  • Huiyi Yan,
  • Chan He,
  • Wenan Peng,
  • Chuliang Tang,
  • Chenmin Yao,
  • Hongye Yang,
  • Cui Huang

摘要

Objectives

This work aims to develop a novel filler system by using resveratrol-loaded hollow mesoporous silica (HMS) to enhance the mechanical properties and reduce cytotoxicity of dental resin cement.

Materials & Methods

HMS was synthesised via an ammonia-catalysed sol–gel process. Resveratrol (Res) was encapsulated by HMS to obtain Res@HMS. Res@HMS was characterised via transmission electron microscopy, dynamic light scattering, nitrogen adsorption/desorption measurements, fourier transform infrared spectroscopy and thermogravimetric analysis. An experimental resin cement containing Res@HMS was prepared. The mechanical properties of resin cement were measured, including flexural strength, elastic modulus and Shore hardness. The in vitro cytotoxicity of resin cement was evaluated via CCK8, lactate dehydrogenase assay and reactive oxygen species measurement.

Results

A Res@HMS filler system with hollow mesoporous structure and the ability to encapsulate large amounts of resveratrol was successfully synthesised. This experimental resin cement modified by Res@HMS exhibited remarkable mechanical properties, especially against thermocycling ageing. The introduction of Res@HMS effectively protected human gingival fibroblasts against resin monomer-induced cytotoxicity.

Conclusion

Res@HMS can serve as a versatile modifier to optimise dental resin cement. This modification can preserve the long-term mechanical properties of dental cement and also reduce resin monomer-induced cytotoxicity.

Clinical significance

The effective integration of mesoporous nanoparticles with plant extracts offers a novel filler that promises to balance the mechanical properties and cytotoxicity of resin cement, paving the way for developing a new generation of dental restorative materials.