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<p>In this work, a solvent evaporation casting approach was used to prepare ZnO@PDA/Zein nanocomposite films, where polydopamine-modified zinc oxide nanoparticles (ZnO@PDA NPs) were incorporated into a zein matrix as the film-forming agent. This nanocomposite film adhered uniformly to the surface of oral therapeutic instruments and exhibited good antibacterial effects. At a doping concentration of 1.2&#xa0;mg/mL, the film exhibited an antibacterial effect against Gram-negative bacteria such as <i>Escherichia coli (E. coli)</i>, and at a doping concentration of 0.6&#xa0;mg/mL, the film exhibited antibacterial effects against Gram-positive bacteria such as <i>Staphylococcus aureus (S. aureus)</i> and <i>Streptococcus mutans (S. mutans)</i>, along with good biocompatibility. This study introduces a novel ZnO@PDA/Zein nanocomposite film with enhanced antibacterial efficacy and biocompatibility, offering a promising solution for preventing biofilm formation on oral therapeutic instruments.</p>

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Antibacterial properties of polydopamine-modified ZnO nanoparticles composite films for oral therapeutic applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月6日

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  • Lei Jin,
  • Junping Fan,
  • Xin Zhu,
  • Shen Wang,
  • Yaoxi Yang,
  • Dongfang Li

摘要

In this work, a solvent evaporation casting approach was used to prepare ZnO@PDA/Zein nanocomposite films, where polydopamine-modified zinc oxide nanoparticles (ZnO@PDA NPs) were incorporated into a zein matrix as the film-forming agent. This nanocomposite film adhered uniformly to the surface of oral therapeutic instruments and exhibited good antibacterial effects. At a doping concentration of 1.2 mg/mL, the film exhibited an antibacterial effect against Gram-negative bacteria such as Escherichia coli (E. coli), and at a doping concentration of 0.6 mg/mL, the film exhibited antibacterial effects against Gram-positive bacteria such as Staphylococcus aureus (S. aureus) and Streptococcus mutans (S. mutans), along with good biocompatibility. This study introduces a novel ZnO@PDA/Zein nanocomposite film with enhanced antibacterial efficacy and biocompatibility, offering a promising solution for preventing biofilm formation on oral therapeutic instruments.