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<p>Ovarian cancer is a common malignancy affecting the female reproductive system. Curcumin (Cur) demonstrates potential as a treatment for ovarian cancer, but creating an effective curcumin-based drug delivery system remains challenging. The advent of the Zeolitic Imidazolate Framework (ZIF) system offers a novel approach for antitumor drug delivery. In this study, effective drug delivery to ovarian cancer cells was accomplished through the construction of a ZIF-based nanodrug delivery system, ZIF-Cur, that encapsulates curcumin. We verified that Cur delivered by ZIF enhanced mitochondrial ROS accumulation in tumor cells, thereby killing tumor cells. The system showed the well biosafety profile, offering a insight therapeutic perspective for ovarian cancer treatment.</p>

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A curcumin-enabled ZIF8 nanosystem enables ovarian cancer treatment by inducing mitochondrial disruption

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月6日

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  • Zhishan Zhang,
  • Genghui Luo,
  • Xiaoxia Tang,
  • Xiubin Ma,
  • Weitao Huang,
  • Bin Wang,
  • Xueying Meng,
  • Caiyan He,
  • Xiaoman Cai,
  • Ping Zhang,
  • Shiyou Luo

摘要

Ovarian cancer is a common malignancy affecting the female reproductive system. Curcumin (Cur) demonstrates potential as a treatment for ovarian cancer, but creating an effective curcumin-based drug delivery system remains challenging. The advent of the Zeolitic Imidazolate Framework (ZIF) system offers a novel approach for antitumor drug delivery. In this study, effective drug delivery to ovarian cancer cells was accomplished through the construction of a ZIF-based nanodrug delivery system, ZIF-Cur, that encapsulates curcumin. We verified that Cur delivered by ZIF enhanced mitochondrial ROS accumulation in tumor cells, thereby killing tumor cells. The system showed the well biosafety profile, offering a insight therapeutic perspective for ovarian cancer treatment.