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Background <p>Data from the real-world REVIEW (Real-world EVidence and Insights into Experiences With eptinezumab) study demonstrated that, after starting treatment with eptinezumab, individuals with chronic migraine (CM) experienced double the number of good days per month and high rates of satisfaction with eptinezumab. This post-hoc analysis explored the associations between self-reported changes in good days per month and other health-related outcome measures and the utility of good days per month as a patient-centric measure of the composite impact of migraine and migraine treatment on an individual.</p> Methods <p>REVIEW was an observational, multi-site study designed to evaluate real-world experiences of patients treated with eptinezumab. A survey was administered to adults with CM who had completed ≥ 2 treatment cycles with eptinezumab. These post hoc analyses evaluated the impact of eptinezumab treatment on the ability to achieve a ≥ 50% and ≥ 75% increase in self-reported good days per month, and the association between these improvements and migraine symptoms, elements of daily living, overall well-being, and brain fog. Results are reported for the subgroups defined by the percentage change in self-reported good days per month after initiating eptinezumab treatment relative to before initiation (≥ 75% increase vs. &lt; 75% and ≥ 50% increase vs. &lt; 50%).</p> Results <p>Following eptinezumab initiation, ≥ 75% and ≥ 50% increases in good days per month were reported by 59/92 (64%) and 70/92 (76%) evaluable participants, respectively. Participants with ≥ 75% increase in good days per month also reported a greater positive impact on multiple migraine symptom domains (68%–90%), as well as select aspects of daily living and overall well-being (73%–90%) compared with participants with &lt; 75% increase (27%–61% and 18%–39%, respectively). Moderate to complete improvement in brain fog after eptinezumab was reported by 77% of participants in the ≥ 75% increase subgroup versus 42% in the &lt; 75% subgroup. Results were consistent for the ≥ 50% increase versus &lt; 50% subgroups.</p> Conclusions <p>Following eptinezumab treatment, most participants reported substantial increases in good days per month, with those experiencing ≥ 75% improvement also reporting greater improvements across multiple migraine symptom domains, daily functioning, overall well-being, and brain fog. These real-world data underscore the importance of novel, patient-centered approaches to understand how preventive therapies can reduce multiple aspects of migraine burden.</p> Trial registration <p>N/A.</p>

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Associations between good days per month and migraine-related disease impact in the real-world: a post hoc analysis from the REVIEW study of eptinezumab in chronic migraine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月26日

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  • Fawad A. Khan,
  • Steven P. Herzog,
  • Ryan M. Smith,
  • Dawn C. Buse,
  • Seema Soni-Brahmbhatt,
  • Susanne F. Awad,
  • S. Wald Grossman,
  • Divya Asher,
  • Foram Patel,
  • Charles Argoff

摘要

Background

Data from the real-world REVIEW (Real-world EVidence and Insights into Experiences With eptinezumab) study demonstrated that, after starting treatment with eptinezumab, individuals with chronic migraine (CM) experienced double the number of good days per month and high rates of satisfaction with eptinezumab. This post-hoc analysis explored the associations between self-reported changes in good days per month and other health-related outcome measures and the utility of good days per month as a patient-centric measure of the composite impact of migraine and migraine treatment on an individual.

Methods

REVIEW was an observational, multi-site study designed to evaluate real-world experiences of patients treated with eptinezumab. A survey was administered to adults with CM who had completed ≥ 2 treatment cycles with eptinezumab. These post hoc analyses evaluated the impact of eptinezumab treatment on the ability to achieve a ≥ 50% and ≥ 75% increase in self-reported good days per month, and the association between these improvements and migraine symptoms, elements of daily living, overall well-being, and brain fog. Results are reported for the subgroups defined by the percentage change in self-reported good days per month after initiating eptinezumab treatment relative to before initiation (≥ 75% increase vs. < 75% and ≥ 50% increase vs. < 50%).

Results

Following eptinezumab initiation, ≥ 75% and ≥ 50% increases in good days per month were reported by 59/92 (64%) and 70/92 (76%) evaluable participants, respectively. Participants with ≥ 75% increase in good days per month also reported a greater positive impact on multiple migraine symptom domains (68%–90%), as well as select aspects of daily living and overall well-being (73%–90%) compared with participants with < 75% increase (27%–61% and 18%–39%, respectively). Moderate to complete improvement in brain fog after eptinezumab was reported by 77% of participants in the ≥ 75% increase subgroup versus 42% in the < 75% subgroup. Results were consistent for the ≥ 50% increase versus < 50% subgroups.

Conclusions

Following eptinezumab treatment, most participants reported substantial increases in good days per month, with those experiencing ≥ 75% improvement also reporting greater improvements across multiple migraine symptom domains, daily functioning, overall well-being, and brain fog. These real-world data underscore the importance of novel, patient-centered approaches to understand how preventive therapies can reduce multiple aspects of migraine burden.

Trial registration

N/A.