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Background <p>Migraine-like headaches can accompany or be the initial manifestation of many neurological disorders. When a migraine-like headache develops or worsens in the presence of another neurological disorder, there is often uncertainty about whether the headache is true migraine (i.e., the primary headache) or is a secondary headache with migraine-like symptoms. To answer this question, we analyzed headache characteristics and the effect of treatment in several neurological disorders.</p> Materials and methods <p>The study was a retrospective analysis of five existing datasets collected by the authors: 1) 670 patients with acute ischemic cerebrovascular disease (550 patients with first-ever ischemic stroke, mean age 63.1&#xa0;years, 46% females and 120 patients with transient ischemic attacks—TIA, mean age 56.1&#xa0;years, 54.2% females); 2) 199 patients with intracranial saccular aneurysms (mean age 43.2&#xa0;years, 52% females); 3) 77 patients with newly diagnosed definite idiopathic intracranial hypertension (IIH) (mean age 28.8&#xa0;years, 96% females); 4) 169 patients with post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) (mean age 41.5&#xa0;years, 52.1% females); 5) 59 patients with PTH followed prospectively with a focus on treatment response to prophylactic migraine medication (mean age 37.1&#xa0;years, 78% females). Detailed information about headache characteristics and outcomes were collected.</p> Results <p>Our results demonstrate that a headache phenotypically fulfilling the diagnostic criteria for 1.1 Migraine without aura and/or 1.2 Migraine with aura can be due to a causative disorder with the following incidence: 13.3% in TIA, 6.9% in ischemic stroke, 44.2% in saccular intracranial aneurysm, 51.9% in IIH, 70.8% in acute PTH, and 90% in persistent PTH. Among individuals who had acute headache following stroke, 45.4% developed persistent headache. These headaches attributed to a secondary cause often responded poorly to migraine treatment, at least suggesting that they differ from primary migraine. The migraine-like headaches disappeared after treatment or remission of the causative disorder in 38.5% of cases with IIH, and 47.7% after clipping of intracranial aneurysms, an outcome that would not be expected if the headaches were primary migraine.</p> Conclusion <p>Our study supports the ICHD-3 statement that migraine-like headache attributed to a secondary cause should be coded as a secondary headache of the migraine type and that it is a migraine mimic attributed to a causative disorder.</p> Graphical abstract <p></p>

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Migraine-like headache attributed to a causative disorder: primary migraine or secondary headache with a migraine-like phenotype?

  • 期刊论文

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  • 发表日期：

    2025年10月23日

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  • Elena R. Lebedeva,
  • Todd J. Schwedt,
  • Catherine D. Chong,
  • Denis V. Gilev,
  • Nadja Skadkær Hansen,
  • Rigmor Højland Jensen,
  • Henrik W. Schytz,
  • Jes Olesen

摘要

Background

Migraine-like headaches can accompany or be the initial manifestation of many neurological disorders. When a migraine-like headache develops or worsens in the presence of another neurological disorder, there is often uncertainty about whether the headache is true migraine (i.e., the primary headache) or is a secondary headache with migraine-like symptoms. To answer this question, we analyzed headache characteristics and the effect of treatment in several neurological disorders.

Materials and methods

The study was a retrospective analysis of five existing datasets collected by the authors: 1) 670 patients with acute ischemic cerebrovascular disease (550 patients with first-ever ischemic stroke, mean age 63.1 years, 46% females and 120 patients with transient ischemic attacks—TIA, mean age 56.1 years, 54.2% females); 2) 199 patients with intracranial saccular aneurysms (mean age 43.2 years, 52% females); 3) 77 patients with newly diagnosed definite idiopathic intracranial hypertension (IIH) (mean age 28.8 years, 96% females); 4) 169 patients with post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) (mean age 41.5 years, 52.1% females); 5) 59 patients with PTH followed prospectively with a focus on treatment response to prophylactic migraine medication (mean age 37.1 years, 78% females). Detailed information about headache characteristics and outcomes were collected.

Results

Our results demonstrate that a headache phenotypically fulfilling the diagnostic criteria for 1.1 Migraine without aura and/or 1.2 Migraine with aura can be due to a causative disorder with the following incidence: 13.3% in TIA, 6.9% in ischemic stroke, 44.2% in saccular intracranial aneurysm, 51.9% in IIH, 70.8% in acute PTH, and 90% in persistent PTH. Among individuals who had acute headache following stroke, 45.4% developed persistent headache. These headaches attributed to a secondary cause often responded poorly to migraine treatment, at least suggesting that they differ from primary migraine. The migraine-like headaches disappeared after treatment or remission of the causative disorder in 38.5% of cases with IIH, and 47.7% after clipping of intracranial aneurysms, an outcome that would not be expected if the headaches were primary migraine.

Conclusion

Our study supports the ICHD-3 statement that migraine-like headache attributed to a secondary cause should be coded as a secondary headache of the migraine type and that it is a migraine mimic attributed to a causative disorder.

Graphical abstract