Scholarlink

Background <p>Repetitive subconcussive impacts are linked to headache pathophysiology, yet the role of electroencephalography (EEG) microstates and cross-frequency coupling in repetitive subconcussive (SC) neural alterations remains unclear. This study investigated microstate-specific cross-frequency coupling network (MCFCN) abnormalities in SC-exposed individuals to uncover mechanisms underlying headache vulnerability.</p> Methods <p>Resting-state EEG was recorded from 16 experienced male parachuters aged 18–25 years (SC group) and 16 demographically matched healthy male controls of the same age range (HC group). Microstate analysis (four canonical classes: A-D) and cross-frequency coupling (CFC) interactions (n: m) phase synchronization index, PSI) were computed to construct the MCFCNs. The MCFCNs were evaluated using machine learning (LightGBM classifier) to discriminate between the two groups, with key features identified by SHAP values and corrected for multiple comparisons.</p> Results <p>SC-exposed individuals exhibited MCFCN disruptions in large-scale networks. Notably, reduced delta/theta to alpha/beta coupling was observed in microstates A, C, and D, except for an increase in delta-band coupling from the default mode network (DMN) to the frontoparietal network (FPN) in microstate A. These alterations involved emotional-motor integration, attentional control, and self-referential processing. LightGBM models achieved significant group discrimination, with SHAP analysis highlighting theta-DMN, beta-SMN, and delta-LIM as critical nodes.</p> Conclusions <p>SC exposure induces MCFCNs abnormalities resembling central pain syndromes, even in the absence of overt symptoms. These findings suggest that interactions within MCFCNs may serve as potential early biomarkers for headache vulnerability and chronicity, warranting further exploration in longitudinal studies and targeted neurointerventions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Neural oscillation mechanisms of repetitive subconcussive impacts: a network study of microstate-specific cross-frequency coupling

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月30日

查看全文
  • Yida He,
  • Huanhuan Li,
  • Xiang Li,
  • Zhenghao Fu,
  • Lida Chen,
  • Lijie Gao ,
  • Junfeng Gao,
  • Jian Song

摘要

Background

Repetitive subconcussive impacts are linked to headache pathophysiology, yet the role of electroencephalography (EEG) microstates and cross-frequency coupling in repetitive subconcussive (SC) neural alterations remains unclear. This study investigated microstate-specific cross-frequency coupling network (MCFCN) abnormalities in SC-exposed individuals to uncover mechanisms underlying headache vulnerability.

Methods

Resting-state EEG was recorded from 16 experienced male parachuters aged 18–25 years (SC group) and 16 demographically matched healthy male controls of the same age range (HC group). Microstate analysis (four canonical classes: A-D) and cross-frequency coupling (CFC) interactions (n: m) phase synchronization index, PSI) were computed to construct the MCFCNs. The MCFCNs were evaluated using machine learning (LightGBM classifier) to discriminate between the two groups, with key features identified by SHAP values and corrected for multiple comparisons.

Results

SC-exposed individuals exhibited MCFCN disruptions in large-scale networks. Notably, reduced delta/theta to alpha/beta coupling was observed in microstates A, C, and D, except for an increase in delta-band coupling from the default mode network (DMN) to the frontoparietal network (FPN) in microstate A. These alterations involved emotional-motor integration, attentional control, and self-referential processing. LightGBM models achieved significant group discrimination, with SHAP analysis highlighting theta-DMN, beta-SMN, and delta-LIM as critical nodes.

Conclusions

SC exposure induces MCFCNs abnormalities resembling central pain syndromes, even in the absence of overt symptoms. These findings suggest that interactions within MCFCNs may serve as potential early biomarkers for headache vulnerability and chronicity, warranting further exploration in longitudinal studies and targeted neurointerventions.