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<p>Chronic neuropathic pain (CNP) results from disease or damage within the somatosensory nervous system. It represents a prevalent and challenging form of chronic pain that exerts a severe impact on patients’ quality of life. This review aims to synthesize and highlight the current understanding of the mechanisms underlying CNP, as well as the evolving therapeutic landscape. With advancements in research, an increasing number of analgesic targets specific to various disease types are being developed, alongside the emergence of novel nanomaterials for treating chronic pain. In this review, we systematically summarize the applications and potential mechanisms of nanomaterials in treating CNP induced by various diseases, providing new insights for both fundamental research and clinical management of CNP.</p>

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Emerging treatments for chronic neuropathic pain from a cross-disease perspective: developments and applications of nanomaterials

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月17日

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  • Rui Sun,
  • Xiaoqin Zhang,
  • Tao Dou,
  • Zhiyi Xiao,
  • Xiaoran Deng

摘要

Chronic neuropathic pain (CNP) results from disease or damage within the somatosensory nervous system. It represents a prevalent and challenging form of chronic pain that exerts a severe impact on patients’ quality of life. This review aims to synthesize and highlight the current understanding of the mechanisms underlying CNP, as well as the evolving therapeutic landscape. With advancements in research, an increasing number of analgesic targets specific to various disease types are being developed, alongside the emergence of novel nanomaterials for treating chronic pain. In this review, we systematically summarize the applications and potential mechanisms of nanomaterials in treating CNP induced by various diseases, providing new insights for both fundamental research and clinical management of CNP.