<p>This study elaborated on the potential effects of monotonic loading on a cross-laminated timber (CLT) panel-to-panel orthogonal joint. The joint was subjected to multidirectional loading at various angles when it was connected using the self-tapping screw with varied insertion angle. The load-carrying capacity of two self-tapping screws was investigated under combined out-of-plane tension and in-plane shear directions in this study. The combined load stiffness predominantly aligned with those of in-plane shear direction at smaller angle between the load direction and the major direction of the CLT. As the angle increased, the stiffness contribution shifted progressively toward the out-of-plane tension direction. A new load interaction equilibrium was proposed, offering a compatible method to predict the shared out-of-plane and in-plane capacities under combined loading for such a joint system.</p>