<p>Load-sensing systems use a centralized power source for energy supply and multiway valves for flow distribution and suffer from excessive throttling losses and low energy efficiency. Pump-controlled systems adopt volumetric control methods to eliminate throttling losses. However, pump-controlled multi-actuator systems require excessive installed power. To address these issues, by combining the respective advantages of valve- and pump-controlled technologies, an open–closed circuit integrated pump-valve collaborative drive multi-actuator system consisting of pump- and valve-controlled units is proposed. The pump-controlled units manage the individual actuator motions, whereas the valve-controlled unit enhances the driving power of the pump-controlled units. In addition, to optimize the operation characteristics and energy consumption, a four-quadrant control strategy and an ultralow-pressure loss control strategy were proposed. Several experiments were conducted to evaluate the working performance of the proposed system and the load-sensing system under different working conditions. Experimental results demonstrated that the proposed system exhibited satisfactory velocity control characteristics. Compared with the traditional load-sensing system, the proposed system&#xa0;reduced throttling losses by 90.4−94.4% and energy consumption by 45.9−50.0%. Additionally, only 22.8% of the total energy consumption was attributed to the pump-controlled units, with the remainder provided by the valve-controlled unit. Compared with the traditional pump-controlled multi-actuator system, the proposed system achieved a 29.4% reduction in installed power, thereby lowering the system installed power and costs. This paper presents an electrohydraulic multi-actuator drive method that combines high energy efficiency and high power density and is suitable for electric construction machinery and other heavy equipment with multiple actuators.</p>