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Abstract <p>Currently, studies aimed at creating stimulus-sensitive nanostructured and microstructured drugs, in which the release of a chemotherapeutic agent occurs in a controlled manner under the effect of a certain stimulus, are widespread. This study is devoted to the creation of a polymer model of gefitinib with photoinduced release due to the inclusion of a photosensitizer in the dosage form. The obtained samples are characterized by a particle diameter of up to 150 nm with a rather narrow size distribution. A study of the cytotoxic activity of polymer particles under photoexposure reveals a combined effect of gefitinib and the photosensitizer, with the cytotoxic activity of the samples exceeding the effect of free gefitinib by 1.4–1.7 times.</p>

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Development and Study of the Properties of Polymeric Submicron Particles of Gefitinib with Photoinduced Release

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • L. L. Nikolaeva,
  • E. V. Sanarova,
  • A. P. Kolpaksidi,
  • S. D. Shcheglov,
  • A. A. Rudakova,
  • M. A. Baryshnikova,
  • N. G. Preferanskaya,
  • I. G. Meerovich,
  • A. V. Lantsova

摘要

Abstract

Currently, studies aimed at creating stimulus-sensitive nanostructured and microstructured drugs, in which the release of a chemotherapeutic agent occurs in a controlled manner under the effect of a certain stimulus, are widespread. This study is devoted to the creation of a polymer model of gefitinib with photoinduced release due to the inclusion of a photosensitizer in the dosage form. The obtained samples are characterized by a particle diameter of up to 150 nm with a rather narrow size distribution. A study of the cytotoxic activity of polymer particles under photoexposure reveals a combined effect of gefitinib and the photosensitizer, with the cytotoxic activity of the samples exceeding the effect of free gefitinib by 1.4–1.7 times.