Scholarlink

Abstract <p>The design of spherical ferrogels (FG) for biomedical applications to improve their biocompatibility and visualization is described. Hydrogels and FG with a diameter of ~2.2 mm are synthesized based on calcium alginate and maghemite magnetic nanoparticles (MNPs). The elastic properties of the samples are determined by solving the Hertzian contact problem for the deformation of spheres, and the echogenicity is determined using a medical ultrasound device based on the intensity of the echo signal reflected from the spheres (brightness). The addition of 10-wt-% MNPs to the gel is accompanied by a significant increase in Young’s modulus, brightness at the gel–water boundary, and the emergence of clear visualization of the FG contents. It is likely that the increase in echogenicity at the gel–water boundary reflects the effect of MNPs on the elasticity of FGs, and the echogenicity of the FG contents is associated with the aggregation of MNPs in the polymer.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mechanical and Echogenic Properties of Spherical Ferrogels Based on Alginate and Magnetic Nanoparticles: Focus on Biomedical Applications

  • 期刊论文

  • 发表日期：

    2025年8月1日

查看全文
  • A. V. Bugayova,
  • P. A. Shabadrov,
  • O. A. Dinislamova,
  • T. F. Shklyar,
  • S. Yu. Sokolov,
  • N. M. Kurilova,
  • A. P. Safronov,
  • F. A. Blyakhman

摘要

Abstract

The design of spherical ferrogels (FG) for biomedical applications to improve their biocompatibility and visualization is described. Hydrogels and FG with a diameter of ~2.2 mm are synthesized based on calcium alginate and maghemite magnetic nanoparticles (MNPs). The elastic properties of the samples are determined by solving the Hertzian contact problem for the deformation of spheres, and the echogenicity is determined using a medical ultrasound device based on the intensity of the echo signal reflected from the spheres (brightness). The addition of 10-wt-% MNPs to the gel is accompanied by a significant increase in Young’s modulus, brightness at the gel–water boundary, and the emergence of clear visualization of the FG contents. It is likely that the increase in echogenicity at the gel–water boundary reflects the effect of MNPs on the elasticity of FGs, and the echogenicity of the FG contents is associated with the aggregation of MNPs in the polymer.