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Abstract <p>A combination of materials such as a PVDF-based composite with 10 wt % CoFe<sub>2</sub>O<sub>4</sub> nanoparticles and a method of ME stimulation of stem cells using a perpendicularly shifting low-frequency (0.3 Hz) magnetic field with a given amplitude are proposed. Optimal stimulation parameters—magnetic field strength, number of stimulations per day and duration—are systematically established to maximize the proliferation of multipotent mesenchymal stem cells up to 30% confirmed by WST-1 analysis.</p>

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Tuning the Magnetoelectric Stimulation Method to Enhance Cell Proliferation in PVDF-based Nanocomposites

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • V. Salnikov,
  • V. Antipova,
  • P. Vorontsov,
  • D. Turusheva,
  • A. Ignatov,
  • P. Ershov,
  • K. Levada,
  • A. Omelyanchik,
  • V. Rodionova

摘要

Abstract

A combination of materials such as a PVDF-based composite with 10 wt % CoFe2O4 nanoparticles and a method of ME stimulation of stem cells using a perpendicularly shifting low-frequency (0.3 Hz) magnetic field with a given amplitude are proposed. Optimal stimulation parameters—magnetic field strength, number of stimulations per day and duration—are systematically established to maximize the proliferation of multipotent mesenchymal stem cells up to 30% confirmed by WST-1 analysis.