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Abstract <p>Several types of devices are proposed for closing annulus fibrosus defects after sequestrectomy to restore the biomechanics of the intervertebral disc. Polylactide, poly-ε-caprolactone, and copolymers of lactide and ε-caprolactone are selected as the materials. The compressive modulus values of the materials range from 0.54 to 210 MPa, depending on the composition and structure of the devices being developed. Sponge-type devices made from copolymers of polylactide and polycaprolactone show the most promise for further in vivo research studies.</p>

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Biodegradable Devices Based on Blends of Polylactide and Polycaprolactone and Their Copolymers for the Closure of Fibrosis Annulus Defects after Sequestrectomy of the Intervertebral Disc

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • Yu. D. Zagoskin,
  • V. A. Demina,
  • Yu. S. Fomina,
  • P. V. Dmitryakov,
  • A. A. Stupnikov,
  • A. A. Nesmelov,
  • S. N. Malakhov,
  • M. M. Alexanyan,
  • S. A. Makarov,
  • T. E. Grigoriev,
  • S. N. Chvalun

摘要

Abstract

Several types of devices are proposed for closing annulus fibrosus defects after sequestrectomy to restore the biomechanics of the intervertebral disc. Polylactide, poly-ε-caprolactone, and copolymers of lactide and ε-caprolactone are selected as the materials. The compressive modulus values of the materials range from 0.54 to 210 MPa, depending on the composition and structure of the devices being developed. Sponge-type devices made from copolymers of polylactide and polycaprolactone show the most promise for further in vivo research studies.