Abstract <p>2-Aminopyridine-3-carbonitrile derivatives exhibit high reactivity and can be used as building blocks for further modification and creation of more functionalized derivatives. The main reactions are associated either with reactions of the amino group: alkylation, acylation, condensation and diazotization; or with reactions of the nitrile group: reduction, hydrolysis, addition of nucleophilic reagents. The presence of several reaction centers in the 2-aminopyridine-3-carbonitrile molecule allows the production of condensed derivatives. This review covers the works available from 1978 to 2023, revealing the possibilities of using substituted 2-aminopyridine-3-carbonitriles in organic synthesis.</p>