Biological Activity of Quaternary Ammonium Salts Containing 1,3-Dioxolane or gem-Dichlorocyclopropane Fragment

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发表日期：

2024年3月1日

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G. Z. Raskil’dina,
Yu. G. Borisova,
A. N. Vereshchagin,
E. V. Detusheva,
R. M. Sultanova,
S. S. Zlotskii

摘要

Abstract

Quaternary ammonium salts (QASs) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane fragments were prepared in 40–90% yields based on pyridine, hexamethylenetetramine, and tertiary amines. The structures of the obtained salts were identified by ¹H and ¹³C NMR spectroscopy. The antibacterial activity of QAS against a bacterial strain (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinobacter Baumanii) were assessed. Among the salts tudied, leader compounds were identified that exhibited high antibacterial activity.