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Abstract <p>In this paper we analyze the research and development in the field of calcium-phosphate materials for the replacement of bone tissue defects, including those with antitumor action—in the case of bone defects resulting from cancer diseases affecting and/or metastasizing to bone tissue. The following databases were used for the analysis: PubMed; Web of Science; The Lens; Espacenet; Information Search System of Federal Institute of Industrial Property (FIIP); digital platform “Rospatent”; Unified State Information System for Accounting of Research, Development and Technological Work of Civil Purpose (EGISU NIOKTR); electronic service of the Federal Service for Surveillance in Healthcare (Roszdravnadzor)—State Register of Medical Devices and Organizations (Individual Entrepreneurs) engaged in the production and manufacturing of medical devices (State Register of medical devices). According to the results of analysis of data in EGISU NIOKTR, the largest number of studies in the field of calcium-phosphate materials for replacement of bone tissue defects were started in Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences (Baikov Institute). A total of 81 research and development (R&amp;D) works in this field are registered in the EGISU NIOKTR, of which only 16% of the works are devoted to obtaining materials intended for the restoration of bone tissue defects and having therapeutic potential, including in the field of oncology. As a result of the analysis of patent documents contained in the above databases, we can conclude that Russian Federation has low patent activity in the field of creation and application of calcium-phosphate materials for replacement of bone tissue defects compared to other countries of the world. Among patent holders from Russia, Baikov Institute is in the first place by the number of patents. The analysis of State Register of medical devices shows that 25 medical devices representing calcium-phosphate materials for bone tissue defects replacement are registered on the Russian market, and 16 of them belong to manufacturers from Russia. At the same time, seven registration certificates have been issued for calcium-phosphate materials, which additionally include active substances or medicinal preparations in their composition, and five of such materials belong to Russian organizations.</p>

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Calcium Phosphate Materials for Osteoplasty and Their Prospects as Anticancer Drug Delivery Systems: a Review of Research and Development

  • 期刊论文

  • 发表日期：

    2026年4月26日

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  • N. A. Lebedeva,
  • E. V. Galitsyna,
  • N. V. Volkova,
  • N. A. Ulyakina

摘要

Abstract

In this paper we analyze the research and development in the field of calcium-phosphate materials for the replacement of bone tissue defects, including those with antitumor action—in the case of bone defects resulting from cancer diseases affecting and/or metastasizing to bone tissue. The following databases were used for the analysis: PubMed; Web of Science; The Lens; Espacenet; Information Search System of Federal Institute of Industrial Property (FIIP); digital platform “Rospatent”; Unified State Information System for Accounting of Research, Development and Technological Work of Civil Purpose (EGISU NIOKTR); electronic service of the Federal Service for Surveillance in Healthcare (Roszdravnadzor)—State Register of Medical Devices and Organizations (Individual Entrepreneurs) engaged in the production and manufacturing of medical devices (State Register of medical devices). According to the results of analysis of data in EGISU NIOKTR, the largest number of studies in the field of calcium-phosphate materials for replacement of bone tissue defects were started in Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences (Baikov Institute). A total of 81 research and development (R&D) works in this field are registered in the EGISU NIOKTR, of which only 16% of the works are devoted to obtaining materials intended for the restoration of bone tissue defects and having therapeutic potential, including in the field of oncology. As a result of the analysis of patent documents contained in the above databases, we can conclude that Russian Federation has low patent activity in the field of creation and application of calcium-phosphate materials for replacement of bone tissue defects compared to other countries of the world. Among patent holders from Russia, Baikov Institute is in the first place by the number of patents. The analysis of State Register of medical devices shows that 25 medical devices representing calcium-phosphate materials for bone tissue defects replacement are registered on the Russian market, and 16 of them belong to manufacturers from Russia. At the same time, seven registration certificates have been issued for calcium-phosphate materials, which additionally include active substances or medicinal preparations in their composition, and five of such materials belong to Russian organizations.