Abstract <p>A technology and installation for conditioning of spent ion-exchange resins by dehydration and inclusion in a polymer binder have been developed. Radiation resistance of the polymer compound obtained has been assessed in accordance with regulatory requirements using developed and certified methods. Mechanical strength (compressive strength) has been adopted as an indicator characterizing the structure of the polymer compound. It has been found that, at a radiation dose of 10⁴ Gy, the strength of the composition under study increases, and this is due to the radiation crosslinking phenomenon, which leads to the formation of additional chemical bonds and strengthening of the matrix. The volume of polymer compound samples when irradiated with doses of 10⁴–10⁶ Gy decreases, which guarantees the integrity of containers used for its storage/burial. The rate of radionuclide leaching from polymer compound samples during irradiation also decreases and is within the requirements of NP-019-15. The compliance of the polymer compound with the normative requirements of radiation resistance in terms of invariability of its structure and water resistance is shown.</p>