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Abstract <p>A two-layer bioresorbable&#xa0;vascular graft&#xa0;(BVG) with an internal diameter of 2 mm has been developed from biopolymer bioresorbable materials: synthetic polymer polycaprolactone and high-molecular compound of natural origin—gelatin. BVG has a highly porous structure, physical and mechanical characteristics close to a natural blood vessel of a similar diameter, and water permeability of less than 10 mL/(cm<sup>2</sup> min). The graft is biocompatible and, when implanted into the infrarenal aorta of a rat, demonstrates blood flow parameters (systolic and diastolic velocity and resistivity index) close to the corresponding parameters of the rat aorta. Under in vivo functioning conditions, the two-layer vascular graft is resistant to stratification and does not provoke an inflammatory reaction, and after 8 weeks of functioning, the formation of neointima is observed on the inner surface of the BVG against the background of the integration of the graft into the body’s surrounding tissues.</p>

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Small-Diameter Biopolymer Vascular Graft Made of Bioresorbable Materials

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • E. A. Nemets,
  • V. Yu. Belov,
  • N. V. Grudinin,
  • V. K. Bogdanov,
  • L. A. Kirsanova,
  • V. A. Ryzhikova,
  • Yu. B. Basok,
  • V. I. Sevastianov

摘要

Abstract

A two-layer bioresorbable vascular graft (BVG) with an internal diameter of 2 mm has been developed from biopolymer bioresorbable materials: synthetic polymer polycaprolactone and high-molecular compound of natural origin—gelatin. BVG has a highly porous structure, physical and mechanical characteristics close to a natural blood vessel of a similar diameter, and water permeability of less than 10 mL/(cm2 min). The graft is biocompatible and, when implanted into the infrarenal aorta of a rat, demonstrates blood flow parameters (systolic and diastolic velocity and resistivity index) close to the corresponding parameters of the rat aorta. Under in vivo functioning conditions, the two-layer vascular graft is resistant to stratification and does not provoke an inflammatory reaction, and after 8 weeks of functioning, the formation of neointima is observed on the inner surface of the BVG against the background of the integration of the graft into the body’s surrounding tissues.