Brushite Boron Cement with Antibacterial Properties

Boron-containing brushite cements (B-BCs) for bone grafting based on boron-substituted β-tricalcium phosphate (B-TCP) are developed. The phase composition and microstructure of B-BCs are studied. It is shown that the crystalline phase of brushite is formed as a result of hardening of the cements. The behavior of B-BCs in a physiological saline containing a TRIS buffer is studied. The compression strength of B-BCs within 5 days after blending is 22.5 ± 1 MPa. Studies of antibacterial activity against the E. coli gram-negative strain ATCC25922 and S. aureus gram-positive strain ATCC25923 show that boron-containing brushite cement exhibits antibacterial activity against both strains, causing a decrease in the number of colony forming units (CFUs) already after 3 h of incubation. In vitro studies of the developed B-BCs are carried out, and it is shown that the developed cements based on TCP and B-TCP are biocompatible and promising for use in bone tissue surgery.