Innovative Approaches in Nanomedicine: Atomic Layer Deposition of Antibacterial Nanofilms and Their Application in the Treatment of Chronic Wounds
摘要
The paper presents a review of the application of nanotechnology in medicine (nanomedicine) in Russia and abroad. Particular attention is paid to the development and implementation of antibacterial nanocoatings for medical implants and instruments, as well as the role of nanomaterials in accelerating the healing of chronic wounds. Antibacterial nanomaterials can become a new stage in modern medicine in the treatment of bacterial infections due to their high efficiency, high strength and wear resistance. The paper provides a comparative analysis of such methods for the synthesis of antibacterial nanocoatings as the sol-gel method, chemical and physical vapor deposition (CVD, PVD), and atomic layer deposition (ALD). ALD technology allows creating antibacterial biocompatible nanofilms on various surfaces with high adhesion and strength, which increases the reliability and performance characteristics of such nanocoatings. Such nanofilms can be applied to implants to impart antibacterial and biocompatible properties to them in order to prevent postoperative complications. Dressings with antibacterial nanocoatings promote accelerated and safe healing of wounds, including chronic ones. The proposed technology can be used to manufacture dressings of a new type for accelerated wound healing.