Novel Organotin Complexes with Losartan: Synthesis and Biological Activity

期刊论文
发表日期：

2024年12月1日

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T. A. Antonenko,
O. A. Raykova,
Yu. A. Gracheva,
D. M. Mazur,
V. A. Roznyatovsky,
R. I. oglu Musaev,
N. A. Gurova,
M. S. Pshenichnikova,
D. S. Yakovlev,
E. R. Milaeva,
A. A. Spasov

摘要

Abstract

Novel organotin(IV) complexes based on losartan have been synthesized and characterized by ¹H, ¹³C, ¹¹⁹Sn NMR, IR, ESI-MS and elemental analysis. The antiproliferative activity of the complexes was assessed in vitro against human cancer cells, while their cytotoxic effects were examined on primary rat skin fibroblasts. The compounds exhibited strong activity, significantly inducing apoptosis. Additionally, they effectively suppressed the spasmogenic effect induced by angiotensin II in isolated rat portal veins.