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Abstract <p>The effect of astaxanthin (5 and 10 μM), a carotenoid xanthophyll, on the viability of human AC16 cardiomyocytes under the cytotoxic action of 100 μM hydrogen peroxide was investigated. It was shown that the combined action of these substances leads to an increase in cell viability and mitotic activity index. It was established that against the background of cytotoxicity caused by hydrogen peroxide, astaxanthin contributes to a decrease in the content of protein kinase R-like endoplasmic reticulum kinase (PERK) and endoplasmic reticulum stress stimulator and homologous protein of proapoptotic transcription factor C/BEP (CHOP). Astaxanthin has been shown to restore the expression of anti- and pro-apoptotic proteins of the Bcl-2 family in hydrogen peroxide-induced cytotoxicity. The protective effect of astaxanthin was observed despite the toxic effects of hydrogen peroxide.</p>

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Astaxanthin Prevents Hydrogen Peroxide Induced Decrease in the Viability of AC16 Cardiomyocytes

  • 期刊论文

  • 发表日期：

    2026年5月20日

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  • A. I. Lomovsky,
  • Yu. L. Baburina,
  • Ya. V. Lomovskaya,
  • R. R. Krestinin,
  • L. D. Sotnikova,
  • O. V. Krestinina

摘要

Abstract

The effect of astaxanthin (5 and 10 μM), a carotenoid xanthophyll, on the viability of human AC16 cardiomyocytes under the cytotoxic action of 100 μM hydrogen peroxide was investigated. It was shown that the combined action of these substances leads to an increase in cell viability and mitotic activity index. It was established that against the background of cytotoxicity caused by hydrogen peroxide, astaxanthin contributes to a decrease in the content of protein kinase R-like endoplasmic reticulum kinase (PERK) and endoplasmic reticulum stress stimulator and homologous protein of proapoptotic transcription factor C/BEP (CHOP). Astaxanthin has been shown to restore the expression of anti- and pro-apoptotic proteins of the Bcl-2 family in hydrogen peroxide-induced cytotoxicity. The protective effect of astaxanthin was observed despite the toxic effects of hydrogen peroxide.