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Abstract <p>This analytical review considers the main elements of mitochondrial restructuring that occurs in eukaryotes forced to live in hypoxic conditions for a long time. In these organisms, mitochondria retain their activity, not only synthetic and signaling, but also bioenergetic, albeit to a lesser extent. The reorganization, primarily accompanied by the reversal of the succinate dehydrogenase reaction and the presence of low-potential quinone, allows organisms to obtain energy exclusively from complex I in mitochondria. A comprehensive review of all changes caused by constant exposure to hypoxic conditions allows us to develop an anti-hypoxic strategy that eliminates the influence of undesirable factors associated with hypoxic changes. On the other hand, understanding all elements of hypoxia-induced changes makes it possible to use them in combating solid tumor cells that live in the oxygen-deprived microenvironment.</p>

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The Potential for Using the Mechanism of Hypoxic Adaptation in Lower Eukaryotes

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • D. B. Zorov,
  • L. D. Zorova,
  • V. A. Babenko,
  • D. S. Semenovich,
  • A. E. Ivanova,
  • S. D. Zorov,
  • I. B. Pevzner,
  • E. Y. Plotnikov,
  • D. N. Silachev,
  • G. T. Sukhikh

摘要

Abstract

This analytical review considers the main elements of mitochondrial restructuring that occurs in eukaryotes forced to live in hypoxic conditions for a long time. In these organisms, mitochondria retain their activity, not only synthetic and signaling, but also bioenergetic, albeit to a lesser extent. The reorganization, primarily accompanied by the reversal of the succinate dehydrogenase reaction and the presence of low-potential quinone, allows organisms to obtain energy exclusively from complex I in mitochondria. A comprehensive review of all changes caused by constant exposure to hypoxic conditions allows us to develop an anti-hypoxic strategy that eliminates the influence of undesirable factors associated with hypoxic changes. On the other hand, understanding all elements of hypoxia-induced changes makes it possible to use them in combating solid tumor cells that live in the oxygen-deprived microenvironment.