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Abstract <p>JAK2, one of the tyrosine Kinases belonging to the Janus Kinase family, is involved in cytokine-mediated cellular signaling. Overactivation of JAK2 has been linked to various malignancies including cancer and other autoimmune disorders. Hence, regulation of JAK2 makes a suitable therapeutic option in the management of various types of cancers, COVID-19, and other malignancies. This review comprehensively imbibes into the supporting facts to prove the effect of JAK2 overactivation in solid cancers and COVID-19 and the scope of employing JAK2 inhibitors in cases of these malignancies.</p>

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JAK2 Inhibitors as the Elixir for Humans: A Truth or Myth (A Review)

  • 期刊论文

  • 发表日期：

    2025年9月4日

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  • A. S. Achutha,
  • V. L. Pushpa,
  • V. Divya,
  • S. Sarithamol,
  • S. Surendran,
  • K. B. Manoj,
  • V. R. Sunitha,
  • K. B. Jeneena

摘要

Abstract

JAK2, one of the tyrosine Kinases belonging to the Janus Kinase family, is involved in cytokine-mediated cellular signaling. Overactivation of JAK2 has been linked to various malignancies including cancer and other autoimmune disorders. Hence, regulation of JAK2 makes a suitable therapeutic option in the management of various types of cancers, COVID-19, and other malignancies. This review comprehensively imbibes into the supporting facts to prove the effect of JAK2 overactivation in solid cancers and COVID-19 and the scope of employing JAK2 inhibitors in cases of these malignancies.